Intraperitoneal Dexamethasone, Dexmedetomidine, and Dexamethasone-Dexmedetomidine Combination on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy

Phase 3

Recruiting

• Conditions: Laparoscopic Cholecystectomy; Postoperative Nausea and Vomiting
• Interventions: Drug: normal Saline; Drug: Combination of dexamethasone + dexmedetomidine; Drug: Dexmedetomidine; Drug: Dexamethasone

• Registration Number: NCT05988671
• Lead Sponsor: Al-Azhar University

Brief Summary

Nausea and vomiting are some of the most common complaints of patients after any anesthesia, which is often associated with postop-erative pain. The double-blind clinical trial study aimed to compare the prophylactic effect of dexamethasone and dexmedetomidine and their combination in reducing postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-08-04
• Study Start: 2023-08-10
• Study First Submitted QC: 2023-08-10
• Study First Posted: 2023-08-14
• Status Verified: 2024-07
• Last Update Submitted: 2024-07-30
• Last Update Posted: 2024-07-31
• Primary Completion: 2024-08-30
• Study Completion: 2024-08-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Patients aged from 20 - 50 years
• ASA I OR II
• undergo laparoscopic cholecystectomy

Exclusion Criteria

• Patients with history of psychotic illnesses,
• Parkinson's disease
• motion disorder
• Smoker
• or history of chemotherapy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group	normal Saline	received 20 ml normal saline
combined group	Combination of dexamethasone + dexmedetomidine	received combination of both 8mg dexamethasone+ dexmedetomidine 1mic/kg
dexmedetomidine group	Dexmedetomidine	received dexmedetomidine 1mic/kg
dexamethasone group	Dexamethasone	received 8mg dexamethasone

Primary Outcome Measures

Name	Time	Method
The number of patients suffered from postoperative nausea and vomiting will be recorded in each group.	24 hours postoperative

Secondary Outcome Measures

Name	Time	Method
antiemetic consumption	24 hours postoperatively	frequency of antiemetic consumption will be determined

Trial Locations

Locations (2)

Neveen Kohaf; 🇪🇬 Tanta, Egypt

Haney Baumey; 🇪🇬 Banhā, Egypt