Dexamethasone With Super-hydration for Prevention of Postoperative Nausea and Vomiting
- Conditions
- Nausea and Vomiting, Postoperative
- Interventions
- Registration Number
- NCT02726308
- Lead Sponsor
- Assiut University
- Brief Summary
Postoperative nausea and vomiting (PONV) are the most common and distressing side effects following Laparoscopic cholecystectomy
- Detailed Description
In the operating room, standard monitors included electrocardiogram, noninvasive arterial blood pressure, arterial oxygen saturation, and end-tidal carbon dioxide were connected. All patients received standardized anesthetic technique. At the end of surgery, gastric contents were suctioned via an orogastric tube before extubation. Atropine and neostigmine (1/2.5 mg) was given slowly I.V. to antagonize the residual neuromuscular block. Then, the trachea was extubated. Then, patients were transferred to the post-anesthesia care unit in a stable condition. Patients were allowed to drink liquids as soon as requested.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 100
American Society of Anesthesiologists (ASA) physical status I or II aged Elective laparoscopic cholecystectomy
Steroids use within the last 3 days before surgery Antiemetic use within the last 3 days before surgery Opioids use within the last 3 days before surgery. Patients with liver, cardiac or renal diseases Patients with Pregnancy Patients with Bmi ˃ 30kg/m2 Patients with Delayed wound healing Open surgery
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Dexamethasone Group 10 ml/kg Ringer's lactate I.V. Dexamethasone 5 mg just before induction plus intra-operative 10 ml/kg Ringer's lactate solution. Dexamethasone and super-hydration Group 30 ml/kg Ringer's lactate I.V. Dexamethasone 5 mg just before induction of anesthesia plus intraoperative 30 ml/kg Ringer's lactate solution Dexamethasone Group Dexamethasone I.V. Dexamethasone 5 mg just before induction plus intra-operative 10 ml/kg Ringer's lactate solution. Dexamethasone and super-hydration Group Dexamethasone I.V. Dexamethasone 5 mg just before induction of anesthesia plus intraoperative 30 ml/kg Ringer's lactate solution
- Primary Outcome Measures
Name Time Method Postoperative Nausea and Vomiting (PONV) Within the first 24 hours postoperatively A nurse, who was unaware about the groups to which the patient belonged, evaluated patients at 0, 6, and 24 h after surgery for any symptoms of nausea, retching, or vomiting. PONV is classified as early, if occurring up to 6h after surgery, or late, if occurring between 6 h up to 24 postoperatively.
A Verbal Descriptive Scale (VDS), was used to assess the severity of PONV: no PONV (grade 0), mild PONV (grade 1), moderate PONV (grade 2) and severe PONV (grade 3)
- Secondary Outcome Measures
Name Time Method Antiemetic usage Within the first 24 hours postoperatively Total amount of ondansetron consumption (mg)
Total analgesic consumption Within the first 24 hours postoperatively I.V Pethidine (mg)
Pain Score Within the first 24 hours postoperatively A visual analogue scale (appropriate score)
Incidence of delayed wound healing Within the first week postoperatively Number of patients
Total number of patients who had nausea, vomiting or retching Within the first 24 hours postoperatively Total number of patients who had nausea, vomiting or retching (number)
Incidence of wound infection Within the first week postoperatively Number of patients
Trial Locations
- Locations (1)
Faculty of Medicine
🇪🇬Assiut, Egypt