Prevention of post operative nausea and vomiting with dexamethasone in children and adolescents undergoing posterior spinal fusion for adolescent idiopathic scolioses : A randomized double-blind clinical trial
- Conditions
- Adolescent idiopathic scolioses
- Registration Number
- JPRN-UMIN000016847
- Lead Sponsor
- Department of Anesthesiology, Keio University School of Medicine
- Brief Summary
The 72 h incidence of PONV was significantly lower in the dexamethasone group than in the control group (62.5% vs 84.0%; RR 0.74, 95% CI 0.58-0.96, P=0.02). During the first and second 24 h postoperative intervals, fewer patients in the dexamethasone group received rescue antiemetics. Visual analogue scale scores for nausea and pain were lower in the dexamethasone group than in the control group during the first 24 h postoperatively. Dexamethasone did not increase the number of adverse events. The results of this study showed that a single dose of dexamethasone was effective for reducing PONV after paediatric scoliosis correction surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 100
Not provided
Contraindication to the use of any of the study medications. Patients who took steroids or immunosuppressant within 1 month prior to the surgery. Patients who took antiemetics within 24h prior to the surgery.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of PONV within 72h after surgery
- Secondary Outcome Measures
Name Time Method