Intravenous Dexamethasone for Preventing Postoperative Nausea and/or Vomiting in Total Abdominal Hysterectomy: A randomized double-blinded, placebo-controlled trial
- Conditions
- Participants who diagnose with benign gynecologic conditions and scheduled for total abdominal hysterectomy with or without adnexal surgery.Postoperative nausea and vomiting, PONV, dexamethasone, hysterectomy
- Registration Number
- TCTR20240416002
- Lead Sponsor
- Khon Kaen Hospital
- Brief Summary
There was no significant difference in the incidence of PONV within 24 hours between the dexamethasone group and control group. The need for antiemetic drugs was not statistically different between groups, and without serious adverse events in both groups. The dexamethasone group experienced a lesser pain score than the control group at 24 hours after surgery. There was no difference in additional analgesic requirements.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 86
Participants were diagnosed with benign gynecologic conditions and scheduled for total abdominal hysterectomy with or without adnexal surgery.
1.Had a known hypersensitivity to dexamethasone 2. Had conditions that might influence gastrointestinal motility (including previous bowel surgery, previous abdominal irradiation, chronic constipation, pancreatitis, peritonitis, hypothyroidism, and chronic use of drugs that impact intestinal peristalsis 3. Had underlying diabetes mellitus who got poor glycemic control 4. Were immunocompromised (tuberculosis, HIV Infection) 5. Experienced an intraoperative blood loss of more than 1,000 ml or blood loss that required blood transfusion.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of PONV within 24 hours at 24 hours after receiving the intervention Percent
- Secondary Outcome Measures
Name Time Method Additional Drug Requirements within 24 hours after receiving intervention Percent,Side effects of dexamethasone within 24 hours after receiving intervention Percent,Postoperative pain score at 24 hours after receiving intervention Mean,This length of hospital stay After participants were discharge from hospital Mean