Comparison of Intraperitoneal Dexamethasone, Dexmedetomidine, and Dexamethasone-Dexmedetomidine Combination on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy: A Randomized Clinical Trial
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 2
- 主要终点
- The number of patients suffered from postoperative nausea and vomiting will be recorded in each group.
研究概览
简要总结
Nausea and vomiting are some of the most common complaints of patients after any anesthesia, which is often associated with postop-erative pain. The double-blind clinical trial study aimed to compare the prophylactic effect of dexamethasone and dexmedetomidine and their combination in reducing postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged from 20 - 50 years
- •ASA I OR II
- •undergo laparoscopic cholecystectomy
排除标准
- •Patients with history of psychotic illnesses,
- •Parkinson's disease
- •motion disorder
- •or history of chemotherapy
研究组 & 干预措施
Control group
received 20 ml normal saline
干预措施: normal Saline (Drug)
dexamethasone group
received 8mg dexamethasone
干预措施: Dexamethasone (Drug)
dexmedetomidine group
received dexmedetomidine 1mic/kg
干预措施: Dexmedetomidine (Drug)
combined group
received combination of both 8mg dexamethasone+ dexmedetomidine 1mic/kg
干预措施: Combination of dexamethasone + dexmedetomidine (Drug)
结局指标
主要结局
The number of patients suffered from postoperative nausea and vomiting will be recorded in each group.
时间窗: 24 hours postoperative
次要结局
- antiemetic consumption(24 hours postoperatively)
研究者
Neveen Abd El Maksoad Kohaf
Lecturer of Clinical Pharmacy
Al-Azhar University