Effect of target-controlled infusion of remifentanil combined with propofol at different plasma concentrations under monitored anesthesia care (MAC) during vitrectomy
Phase 1
Completed
- Conditions
- anesthesia
- Registration Number
- ChiCTR2300067681
- Lead Sponsor
- Tianjin Eye Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
Patients who <br>1. undergo Vitrectomy under monitored anesthesia care(MAC); <br>2. were 45-59 year old; <br>3. meet the classification I-II of American Society of Anesthesiologists (ASA); <br>4. NYHA grade I-II; <br>5.18.5 <= BMI < 28 kg/m2 and<br>6. given written informed consent were selected.
Exclusion Criteria
Patients weith the following medical history criteria will be excluded from the study: <br>1. Mental illness; <br>2. severe respiratory disease; <br>3. severe cardiovascular system disease; <br>4. history of drug addiction; <br>5. history of motion sickness ; <br>6. history of postoperative nausea and vomiting; <br>7. speech and hearing impairment.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of SpO2 lower than 90%;
- Secondary Outcome Measures
Name Time Method incidence of unanticipated somatokinetic response;partial pressure of CO2 at the end of nasal breath;incidence of oculocardiac reflex;incidence of postoperative nausea and vomiting;total operative bipropofol and plasma bar concentration;operation time;the incidence of oral analgesics within 24 h after operation;verbal rating scale (VRS) score 24 h after operation;satisfaction scores of patients upon discharge;