A clinical test to study Hormone(Oxytocin)level and OXTR gene changes in patients with and without persistent pain after surgery to deliver a baby(Caesarean delivery)
Not Applicable
Completed
- Conditions
- Health Condition 1: O82- Encounter for cesarean delivery without indication
- Registration Number
- CTRI/2020/04/024699
- Lead Sponsor
- Department of Anaesthesia University College of Medical Sciences GTB Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1 Patients of ASA grade I or II undergoing lower segment caesarean section with
Pfannenstiel incision under either spinal or general anaesthesia
2 Patients residing in the vicinity of the hospital
Exclusion Criteria
1 Patients having other causes of chronic pain
2 Patients having chronic neurological disorders
3 Patients having cognitive dysfunction or inability to comprehend various
questionnaires
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Absolute & changes in serum oxytocin levels in patients with and without CPSPTimepoint: At baseline and at the end of 14th week
- Secondary Outcome Measures
Name Time Method 1 Correlation between the Single Nucleotide Polymorphism (SNP) of OXTR gene and risk of CPSP <br/ ><br>2 Incidence of CPSP at the end of 14th week <br/ ><br>3 The neuropathic component of pain using Pain detect questionnaire (PDQ) <br/ ><br>4 Neuropatic Pain Symptom Inventory (NPSI) <br/ ><br>score <br/ ><br>5 Short form-12 (SF-12) questionnaire <br/ ><br>6 Sub-group analysis and comparison of various aforementioned parameters will be done between the patients with and without CPSP and SAB and GA group <br/ ><br>Timepoint: At the end of 1st day, 6th week, 10th week & 14th week