The Effect of Oxytocin on the Acquisition and Consolidation of Trauma-Associated Memories

Not Applicable

Completed

• Conditions: Intrusive Memories
• Interventions: Drug: Oxytocin nasal spray; Drug: Placebos

• Registration Number: NCT03031405
• Lead Sponsor: Charite University, Berlin, Germany

Brief Summary

The purpose of the study is to examine whether oxytocin and oxytocin receptor gene polymorphism affect the development of intrusive memories, a cardinal symptom of PTSD.

Detailed Description

Not available

Study Timeline

• Status Verified: 2017-01
• Study Start: 2017-01-15
• Study First Submitted: 2017-01-18
• Study First Submitted QC: 2017-01-23
• Study First Posted: 2017-01-25
• Primary Completion: 2018-06-30
• Study Completion: 2018-06-30
• Last Update Submitted: 2018-08-19
• Last Update Posted: 2018-08-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 220

Inclusion Criteria

• healthy female volunteers
• German on a native level

Exclusion Criteria

• former or present disorder according to the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5)
• any physical illnesses
• any medication intake (except oral contraceptive)
• history of traumatic experience, e.g. history of sexual abuse or rape
• pregnancy or lactation period
• follicular phase of menstrual cycle for all women not using oral contraceptives

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Oxytocin and trauma film paradigm	Oxytocin nasal spray	-
Placebo and trauma film paradigm	Placebos	-

Primary Outcome Measures

Name	Time	Method
Intrusive memories	four consecutive days	Influence of oxytocin on the development of intrusive memories measured with an intrusion diary

Secondary Outcome Measures

Name	Time	Method
Noradrenergic System (measured with salivary alpha-amylase - u/ml)	Day 1	Influence of oxytocin on the noradrenergic system measured with salivary alpha-amylase
Genetic polymorphism	four consecutive days	Influence of genetic polymorphism of the oxytocin receptor on intrusive memories measured with an intrusion diary
Hypothalamic-pituitary-adrenal (HPA) axis (measured with salivary cortisol - nmol/L)	Day 1	Influence of oxytocin on the HPA-axis measured with salivary cortisol

Trial Locations

Locations (1)

Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin; 🇩🇪 Berlin, Germany