Oxytocin's Effect on the Advantageous- and Disadvantageous-inequity
- Conditions
- Healthy
- Interventions
- Drug: Intranasal placebo
- Registration Number
- NCT06405737
- Lead Sponsor
- University of Electronic Science and Technology of China
- Brief Summary
The main aim of the study is to investigate whether intranasal oxytocin modulates advantageous- and disadvantageous-inequity and whether oxytocin has similar effects on them or not.
- Detailed Description
The main aim of the study is to investigate whether intranasal oxytocin modulates advantageous- and disadvantageous-inequity and its underlying neural mechanisms and whether oxytocin has similar effects on them or not. A double-blinded, placebo-controled, between-subject design is employed in this study. In a randomized order, a total of 80 healthy males are instructed to self-administrated intranasal spray of oxytocin or placebo. A modified inequity decision-making task starts 45 minutes after treatment with behavioral (fairness rating, preference rating and the choice rate of unequal option) and fMRI data being collected during this task. Personality traits of subjects are assessed using validated Chinese version questionnaires including the Beck Depression Inventory (BDI-II), State-Trait Anxiety Inventory (STAI), Autism Spectrum Quotient (ASQ), Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ), Behavioral Inhibition System and Behavioral Activation System Scale (BIS/BAS). Subjects are asked to complete Positive and Negative Affect Schedule (PANAS) when they just arrive, before and after the task.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 80
- Healthy subjects without past or current psychiatric or neurological disorders
- history of head injury
- pregnant,menstruating,taking oral contraceptives
- medical or psychiatric illness.
- excessive head movement (> 3mm) during scanning
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description placebo Intranasal placebo a single dose of 24 international units (IU) of placebo will be administered with 3 puffs of treatment to each nostril. oxytocin Intranasal oxytocin a single dose of 24 international units (IU) of OT will be administered with 3 puffs of treatment to each nostril.
- Primary Outcome Measures
Name Time Method Behavioral index: fairness rating scores 45-75 minutes after treatment administration Participants are instructed to rate their perceived levels of fairness to the allocation using a 9-point Likert scale within 4 seconds (1 = very unfair, 9 = very fair).
Behavioral index: preference rating scores 45-75 minutes after treatment administration Participants are instructed to rate their perceived levels of preference to the allocation using a 9-point Likert scale within 4 seconds (1 = not at all, 9 = very preferable).
Neural indices: fMRI-based measures of the outcome presentation stage 45-75 minutes after treatment administration Functional magnetic resonance imaging (fMRI) is employed to assess participants' blood-oxygen-level dependent signals when they are confronted with monetary allocations (advantageous-inequity, disadvantageous-inequity, and fair).
- Secondary Outcome Measures
Name Time Method Behavioral index: choice rate of unequal option 45-75 minutes after treatment administration Participants are instructed to make a hypothetical choice between the actual allocation in the current trial and the other fair option if they were given another chance to re-choose.
Neural indices: fMRI-based measures of outcome and re-decision stages 45-75 minutes after treatment administration Functional magnetic resonance imaging (fMRI) is employed to assess participants' blood-oxygen-level dependent signals when they are instructed to make a hypothetical choice between the actual allocation in the current trial and the other fair option if they were given another chance to re-choose.
Trial Locations
- Locations (1)
University of Electronic Science and Technology of China (UESTC)
🇨🇳Chengdu, Sichuan, China