NCT00296387已完成3 期
Comparison of the Effects Noted in The ApoB/ApoA-I Ratio Using Rosuvastatin and Atorvastatin in Patients With acUte Coronary Syndrome - CENTAURUS
适应症
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- AstraZeneca
- 入组人数
- 1,160
- 试验地点
- 102
- 主要终点
- Percentage changes in ApoB/ApoA-I levels
研究概览
简要总结
The purpose of this study is to see if rosuvastatin compared to Atorvastatin is effective in treating ACS by decreasing the ApoB/ApoA-1 ratio and if starting statin within 24 h following the onset of the first symptoms is beneficial compared to placebo.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hospital admission for ACS with chest pain or discomfort occurring during rest or with minimal exertion,
- •Percutaneous coronary intervention (PCI) planned,
- •Evidence of coronary artery disease
排除标准
- •Hypersensitivity to statins
- •Any cholesterol lowering medication taken within 1 month prior V1
- •Sustained ST-segment elevation on ECG
结局指标
主要结局
Percentage changes in ApoB/ApoA-I levels
时间窗: from Day 0 to 3 months
次要结局
- Percentage changes in LDL-C(from Day 0 to 1 month and 3 months)
- Percentage changes in the hs-CRP and AUC of hs-CRP levels(from Day -6 to Day 0)
- Percentage changes in ApoA-I(from Day 0 to 1 month)
研究者
研究点 (102)
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