Are Sporadic Colorectal Cancers in Young Distinct From Elderly?

Completed

• Conditions: Colorectal Neoplasms

• Registration Number: NCT05601609
• Lead Sponsor: Seoul National University Bundang Hospital

Brief Summary

In this study, the investigators compared and evaluated the clinicopathological and oncological characteristics of sporadic colorectal cancer (CRC) in young adults without genetic mutations associated with hereditary CRC syndrome and sporadic CRC in elderly individuals.

Detailed Description

The ambiguity in the findings among several previous studies might be because of the difference in the age of the study population, yCRC and eCRC. The family history of CRC and cancer due to Crohn's disease or ulcerative colitis were also not excluded in such previous studies. Most importantly, those studies did not rule out the risk of hereditary cancer through the genetic testing in yCRC. Since hereditary CRC accounts for approximately 34% of those under the age of 35 years, it is necessary to exclude it to accurately compare the clinicopathological characteristics of sporadic cancer developed in yCRC and eCRC.

Study Timeline

• Study Start: 2020-11-11
• Primary Completion: 2021-06-10
• Study Completion: 2022-08-02
• Status Verified: 2022-10
• Study First Submitted: 2022-10-19
• Study First Submitted QC: 2022-10-31
• Last Update Submitted: 2022-10-31
• Study First Posted: 2022-11-01
• Last Update Posted: 2022-11-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1599

Inclusion Criteria

• Histologically confirmed cases of adenocarcinoma in the colon and rectum
• The age at the time of diagnosis should be ≤ 40 years (for yCRC) or ≥ 70 years (for eCRC)
• Genetic testing confirmation of non-hereditary cancer.

Exclusion Criteria

• Inflammatory bowel disease
• A family history of CRC
• A history of other cancers
• Underwent any emergency operation or palliative surgery
• The Amsterdam criteria with mutations in genes associated with APC, MLH1, MSH2, MSH6

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Overall survival outcome in young colorectal cancer (yCRC) and elderly colorectal cancer (eCRC)	The OS was defined as the time period from the date of surgery to the date of death or last follow-up up to 3 years	The 3-year overall survival (OS) in yCRC and eCRC

Secondary Outcome Measures

Name	Time	Method
Cancer-specific survival outcome in young colorectal cancer (yCRC) and elderly colorectal cancer (eCRC)	CSS was defined as the time period from the date of surgery to the date of death from CRC up to 3years	The 3-year cancer-specific survival (CSS) in yCRC and eCRC

Trial Locations

Locations (1)

Seoul National University Bundang Hospital; 🇰🇷 Seongnam-si, Gyeonggi-do, Korea, Republic of