ifedipine and Nicorandil in treatment of severe pre-eclampsia
Not Applicable
Recruiting
- Conditions
- Pregnancy and ChildbirthSevere pre-eclampsia
- Registration Number
- PACTR201803003150307
- Lead Sponsor
- niversity of alexandria
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 140
Inclusion Criteria
1)Greater than 30 weeks of gestation.
2)Uncomplicated severe preeclampsia on the basis of :
a-severe hypertension [systolic blood pressure (SBP) ¿160 mmHg and/or diastolic blood pressure (DBP) ¿110 mmHg].
b-clinically significant proteinuria (0.3 g or more of protein in 24-h urine collection).
Exclusion Criteria
1)Imminence of eclampsia.
2)Chronic hypertension or other concomitant chronic diseases
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method control of blood pressure;changes in doppler ultrasound evaluation of the umbilical artery
- Secondary Outcome Measures
Name Time Method changes in Serum endothelial nitric oxide synthase, antioxidant enzyme, superoxide dismutase blood level. ¿The biomarker of oxidative stress, malondialdehyde (MDA) serum level. ¿Platelet aggregation