Neuromuscular Electrical Stimulation (NMES) and Muscle Protein Accretion (ES-PRO)

Not Applicable

Completed

• Conditions: Sarcopenia
• Interventions: Device: No Enraf Nonius Tensmed S84 for Neuromuscular electrical stimulation (NMES) NMES; Device: Enraf Nonius Tensmed S84 for Neuromuscular electrical stimulation (NMES)

• Registration Number: NCT01615276
• Lead Sponsor: Maastricht University Medical Center

Brief Summary

In the present study, the effect of a bolus of intrinsically labeled milk directly after one-legged NMES will be studied.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2012-05-30
• Study First Submitted QC: 2012-06-07
• Study First Posted: 2012-06-08
• Study Start: 2012-10
• Primary Completion: 2013-01
• Study Completion: 2013-01
• Status Verified: 2013-05
• Last Update Submitted: 2013-05-30
• Last Update Posted: 2013-05-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 10

Inclusion Criteria

• Male
• Age 65 - 85 years
• 18.5 < BMI < 30 kg∙m2

Exclusion Criteria

• Type II diabetes
• All co morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthrosis, arthritis, spasticity/rigidity, all neurological disorders, paralysis, hip/knee surgery).
• Use of anticoagulants, blood diseases, allergy for lidocaine
• Use of NSAIDs and acetylsalicylic acid
• Patients suffering from PKU (Phenylketonuria)
• Presence of implantable cardioverter defibrillator and/or pacemaker
• Performed regular resistance type exercise in the past 6 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Protein ingestion	No Enraf Nonius Tensmed S84 for Neuromuscular electrical stimulation (NMES) NMES	Protein ingestion directly after the contralateral leg received NMES
Protein ingestion after NMES	Enraf Nonius Tensmed S84 for Neuromuscular electrical stimulation (NMES)	Ingestion of intrinsically labeled protein, directly after one hour of Neuromuscular electrical stimulation (NMES)

Primary Outcome Measures

Name	Time	Method
Tracer enrichment in the muscle biopsy	4 hours after protein ingestion

Secondary Outcome Measures

Name	Time	Method
Fractional synthetic rate (FSR)	0-4 hours after protein ingestion

Trial Locations

Locations (1)

Maastricht University Medical Centre; 🇳🇱 Maastricht, Netherlands