TO STUDY THE EFFECT OF PERIPHERAL NEUROPATHY DUE TO VINCRISTINE ON FUNCTIONS IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA
Not Applicable
- Conditions
- Health Condition 1: C910- Acute lymphoblastic leukemia [ALL]
- Registration Number
- CTRI/2022/09/045215
- Lead Sponsor
- Manjusha Vagal
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
(1)Patient diagnosed with Acute lymphoblastic leukaemia.
(2)Patient willing to take entire treatment at Tata memorial hospital.
(3)Patient willing to follow-up for periodic assessments at Tata Memorial Hospital.
Exclusion Criteria
(1)Patients presenting with neurological deficit at baseline assessment.
(2)Pre-morbid neuromuscular disorders (such as traumatic brain injury or cerebral palsy)
(3)Childhood diabetes mellitus induced peripheral neuropathy.
(4)Paediatric cancer patients other than Acute Lymphoblastic Leukaemia
(5)Patients unable to complete <50% of the assessments will be excluded from the analysis
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.To understand the incidence, of sensory and motor symptoms in Acute Lymphoblastic Leukaemia patients receiving chemotherapy involving vincristine. <br/ ><br>2.To understand the course of presentation of sensory and motor symptoms in Acute Lymphoblastic Leukaemia patients receiving chemotherapy involving vincristine <br/ ><br>Timepoint: 1 Baseline assessment followed by weekly assessments during induction phase of administration of vincristine and then monthly assessments until completion of intensive phase of chemotherapy as per protocol
- Secondary Outcome Measures
Name Time Method 3.To examine and record impact of vincristine on Function using Canadian occupational performance measure <br/ ><br>4.To examine and record impact of vincristine on Play participation using Takata play history <br/ ><br>5.To examine and record impact of vincristine on Schooling abilities using a departmental semi-structured interview <br/ ><br>Timepoint: 1 Baseline assessment followed by weekly assessments during induction phase of administration of vincristine and then monthly assessments until completion of intensive phase of chemotherapy as per protocol