NCT00860821已完成不适用
A Randomised, Double-blind, Placebo-controlled, Two-way Crossover, Single-centre Methodologhy Study in Healthy Subjects to Evaluate the Effect of Oral Dosing With AZD8309 on Cells and Inflammatory Biomarkers in Nasal Lavage and Blood After Nasal Challenge With Lipopolysaccharide (LPS).
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- AstraZeneca
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Neutrophil numbers in nasal lavage
研究概览
简要总结
The purpose of this methodology study is to evaluate the effect of AZD8309 on cells and inflammatory biomarkers in nasal lavage and blood after nasal challenge with lipopolysaccharide (LPS)
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy men or healthy, permanently sterilized, women aged 18 to 50 years inclusive, non-smokers or ex-smokers, Body Mass Index 18 to 30 kg/m2 and minimum body weight of 50 kg
- •Blood neutrophil count above 2.2x10^9/L
排除标准
- •Clinical relevant disease and/or abnormality
研究组 & 干预措施
1
Experimental
AZD8309
干预措施: AZD8309 (Drug)
2
Placebo Comparator
Placebo
干预措施: AZD8309 (Drug)
结局指标
主要结局
Neutrophil numbers in nasal lavage
时间窗: 3 times each in the end of two treatment periods
次要结局
- Cells and inflammatory biomarkers in nasal lavage(3 times in the end of the two treatment periods)
- Cells and inflammatory biomarkers in blood(2 times in the beginning and 5 times in the end of the two treatment periods)
研究者
研究点 (1)
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