Physical activity and exercise in adults with congenital heart disease
- Conditions
- Cardiovascular - Other cardiovascular diseasesCongenital heart disease including patients who have had a Fontan procedure, repaired tetralogy of Fallot, arterial switch operation for transposition of great arteries (including Mustard and Senning procedures), as well as patients with uncorrected congenital heart morphology.
- Registration Number
- ACTRN12612000936820
- Lead Sponsor
- Royal Perth Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 30
Patients aged at least 18 years of age who had previously undergone a Fontan procedure, repaired tetralogy of Fallot, arterial switch operation for transposition of great arteries (including Mustard and Senning procedures), as well as patients with uncorrected congenital heart morphology.
History of life-threatening arrhythmias in the absence of an automatic internal cardiac defibrillator
Uncontrolled heart failure (ie, requiring hospitalization and/or intravenous medications within the last month)
Severe aortic stenosis; resting peak systolic gradient >50 mm Hg
Severe pulmonary stenosis, resting peak systolic gradient >50 mm Hg
Severe systemic atrioventricular valve regurgitation
Unmedicated systemic hypertension (>165/100mmHg)
Pregnancy, or planning to become pregnant during the course of the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Endothelium dependent vasodilator function measured by flow mediated dilation[12 weeks];Cardiorespiratory fitness measured by indirect calorimetry during a graded treadmill exercise test[12 weeks];Muscular strength measured using the one-repetition maximum technique[12 weeks]
- Secondary Outcome Measures
Name Time Method Quality of life (SF-36)[12 weeks]