OPTimizing IMaging in APpendicitis.
Completed
- Conditions
- MRI.appendicitismagnetic resonance imaging
- Registration Number
- NL-OMON20262
- Lead Sponsor
- Academisch Medisch Centrum Amsterdam
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 230
Inclusion Criteria
Eligible are adult patients, 18 years or older, with clinically suspected acute appendicitis presenting at the ED. No patients should be excluded based on the clinical condition: ‘clinically obvious’ cases should also be included (restriction see exclusion criteria).
Exclusion Criteria
Excluded are patients with conditions known to be incompatible with MRI use, such as a pacemaker, known claustrophobia, and critically ill patients that need intensive vital organ function monitoring for life-support.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Diagnostic accuracy of MRI in detecting acute appendicitis will be calculated with corresponding 95% confidence intervals, by comparing the results of MRI with the final diagnosis assigned by the expert panel. We will determine the sensitivity, specificity, predictive values, inter-observer agreement and patient acceptance of MRI in a consecutive series of patients suspected for acute appendicitis.
- Secondary Outcome Measures
Name Time Method In a scenario analysis imaging strategies with sequential use of US and CT or MRI will be compared, including a strategy in which CT after a non diagnostic US (i.e. an US examination not confirming the diagnosis acute appendicitis) is replaced by MRI, and MRI in all patients.