Clinical evaluation of MAgnetic Resonance imaging in Coronary heart disease
- Conditions
- Coronary heart diseaseCirculatory System
- Registration Number
- ISRCTN77246133
- Lead Sponsor
- British Heart Foundation
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 750
1. Ages between 35 and 79 years
2. Weight less than 110 kg
3. Suitable for coronary revascularisation if required
4. Clinically stable
5. In sinus rhythm
1. Previous revascularisation
2. Evidence of crescendo angina or acute coronary syndrome
3. Contraindication to MRI imaging (pacemaker, intraorbital debris, intraauricular implants, intracranial clips)
4. Contraindication to adenosine infusion (regular adenosine antagonist medication, asthma/chronic obstructive pulmonary disease, second or third degree atrioventricular heart block, sino-atrial disease)
5. Aged less than 35 years
6. Weight greater than 100 kg
7. Non-sinus rhythm
8. Resting heart rate greater than 100 /min
9. Frequent ventricular ectopy (greater than 3 Ventricular Premature Beats [VPB] per minute)
10. Pregnancy
11. Known adverse reaction to adenosine or gadolinium contrast agent
12. Inability to lie supine for 60 minutes
13. Known chronic renal insufficiency
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The diagnostic performance of MRI to detect significant CHD on x-ray angiography
- Secondary Outcome Measures
Name Time Method 1. The diagnostic performance of current standard clinical investigations of ETT and SPECT<br>2. The cost effectiveness of CMRI in a diagnostic strategy for the systematic investigation of patients with suspected CHD<br>3. Patient's preference of the different strategies for the investigation of suspected CHD