CTRI/2026/03/106409尚未招募4 期
Comparison Of Efficacy Of Dexmedetomidine And Fentanyl As Adjuvant To Levobupivacaine 0.5% In Ultrasound Guided Supraclavicular Brachial Plexus Block In Patients Undergoing Upper Limb Surgeries - A Randomised Clinical Trial
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 入组人数
- 100
- 试验地点
- 1
研究概览
简要总结
| Regional anaesthesia techniques have advantages including excellent pain control, reduced side- effects, and shortened stay in the post anaesthesia care unit. Ultrasound guided regional blocks are considered safer with better success rates. Supraclavicular block has high efficacy for providing anaesthesia in upper limb surgeries. Levobupivacaine with lesser cardiac side effects is the preferred local anaesthetic agent. Dexmedetomidine and Fentanyl is used to reduce the onset time, prolong the analgesic, and motor blockade effect without the systemic side effects and reduce total dose of local anesthetic requirement. Here, in our study we determine the onset and duration of analgesia and compare the hemodynamic parameters with two different drugs of Dexmedetomidine and Fentanyl with 0.5% Levobupivacaine. We also try to find any adverse reaction to the study drugs. A total of 100 patients undergoing upper limb surgeries will be divided into two groups: Group A and Group B by block randomization. Group A will receive 19 ml of 0.5% Levobupivacaine with 1 ml of 0.5mcg/kg Dexmedetomidine and Group B will receive 19 ml of 0.5% Levobupivacaine with 1 ml of 0.5mcg/kg Fentanyl. Duration of analgesia, onset of sensory and motor block, time requirement of rescue analgesia will be studied. Hemodynamic parameters and adverse effects will be recorded. The findings and observations made during the entire study will be tabulated, graphically depicted whenever possible, statistically analysed and inference will be drawn. |
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA Grade I and II scheduled for elective upper limb surgeies.
排除标准
- •1.Patient refusal 2.Local site infections 3.Patients on anticoagulants or bleeding disorders 4.Hypersensitivity to amide group of Local anaesthetic agents and dexmedetomidine.
- •5.Pre-existing neuropathy or neurological disorders of upper limb autonomic neuropathy /peripheral nerve injury 6.Significant cardiac, hepatic or renal disease 7.Pregnancy and lactation.
研究者
Dr Asfaque Alam
Regional Institute of Medical Sciences
研究点 (1)
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