The effects of epidural magnesium on perioperative treatment in patients undergoing thoracic surgery
Not Applicable
Recruiting
- Conditions
- Postoperative pain in thoracic surgery
- Registration Number
- SLCTR/2013/016
- Lead Sponsor
- Department of Anesthesia and Intensive Care
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Adult patients, ASA class I-III undergoing elective thoracic surgery
Exclusion Criteria
Patients with renal or hepatic failure, patients with neuromuscular disorders, AV block II-III degree, morbidly obese and patients preoperatively treated with opioids or calcium channel blockers
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Intraoperative cumulative doses of anesthetic (propofol), muscle relaxant (rocuronium) and analgesic (sufentanil) <br>2. Cumulative epidural doses of local anesthetic (levobupivacain) and analgetic (sufentanil) during first 48hours. <br>3. Plasma levels of magnesium <br>4. Plasma levels of cortisol <br> [1. At the end of the operative period <br>2. At the end of 48 hours <br>3. Plasma level of magnesium: preoperatively, at the end of the procedure and every 8 hours during first 24 hours. <br>4. Plasma level of cortisol: before premedication, 1 hour after the start of the operation, 1 hour after the end of the operation and first postoperative day<br>]<br>
- Secondary Outcome Measures
Name Time Method 1. Pain perception using changes in VAS and TORDA scores <br>2. Incidence of chronic postthoracotomy pain <br> [1. VAS and TORDA scores will be evaluated every 4 hours during first 48 hours post operatively <br>2. Incidence of chronic post-thoracotomy pain will be evaluated 6 months after the surgical procedure <br>]<br>