Behavioral Change Following Alzheimer's Disease (AD) Biomarker Disclosure

Not Applicable

• Conditions: Mild Cognitive Impairment; Alzheimer Disease; Amnestic Mild Cognitive Disorder

• Registration Number: NCT05584241
• Lead Sponsor: University of Michigan

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-10-13
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Enrolling by invitation
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Inclusion Criteria:<br><br> - Diagnosed with Amnestic Mild Cognitive Impairment within the past 12 months,<br><br> - Available PET Aß and tau imaging<br><br>Exclusion Criteria:<br><br> - Significant neurologic diagnosis (e.g., Alzheimer's dementia or other<br> neurodegenerative dementia, Parkinson's disease, seizure disorder, tumor, multiple<br> sclerosis)<br><br> - Neurologic injury (e.g., significant stroke or moderate-severe head injury, defined<br> by loss of consciousness > 5 minutes, presence of significant post-traumatic<br> amnesia, or the need for extended hospitalization or intervention)<br><br> - Motor abnormalities indicative of a non-AD etiology<br><br> - Severe mental illness (e.g., bipolar disorder, psychosis), moderate-severe mood or<br> anxiety disorder, active substance use disorder (o reduce the likelihood of severe<br> psychological distress, participants must screen negative for moderate-severe<br> depressive or anxiety symptoms at study enrollment.)<br><br> - Inability to provide independent informed consent.

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Post-disclosure health behavior change as measured by the health behavior subscale score;Post-disclosure health behavior change as measured by the health communication subscale score;Post-disclosure health behavior change as measured by the advanced planning subscale score;Post-disclosure health behavior change as measured by the research engagement subscale score;Percent participant retention in University of Michigan Memory and Aging Project (UMMAP) study