The comparison between high-flow nasal cannula and continuous positive airway pressure application in the patients with acute exacerbation of chronic obstructive pulmonary disease: Prospective study

Yonsei University, Wonju Severance Christian Hospital0 个研究点目标入组 100 人开始时间: 待定最近更新: 2019年3月11日

适应症

试验速览

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•The patients (age = 45 year-old (yr), smoking history of = 10 pack-year (py)) who hospitalized with severe
•acute exacerbation of chronic obstructive pulmonary disease
•(All of the patients were diagnosed with COPD, according to the criteria established by the GOLD, and fulfilled the requirements of FEV1 < 80% and FEV1/forced vital capacity (FVC) < 70% following inhalation of a bronchodilator. The enrolled patients were also underwent AECOPD with moderate hypercapnic acute respiratory failure (ARF) requiring NIV. Moderate hypercapnic ARF was defined by a partial arterial oxygen tension (PaO2) of less than 60 mmHg (<8.0 kpa) and PaCO2 greater than 45 mmHg (>6.0 kpa) characterized by pH levels between 7.25 and 7.35.)

•bronchial asthma, malignancy including lung cancer, severe cardiovascular disorder including valvular heart disease, recent myocardial infarction (within 3 months), and pacemaker insertion, severe renal insufficiency requiring hemodialysis and neurological diseases including cerebral infarction or hemorrhage

发起方

Yonsei University, Wonju Severance Christian Hospital