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Clinical Trials/KCT0001913
KCT0001913
Active, Not Recruiting
N/A

The comparison between high-flow nasal cannula and continuous positive airway pressure application in the patients with acute exacerbation of chronic obstructive pulmonary disease: Prospective study

Yonsei University, Wonju Severance Christian Hospital0 sites100 target enrollmentTBD

Overview

Phase
N/A
Intervention
Not specified
Conditions
Diseases of th respiratory system
Sponsor
Yonsei University, Wonju Severance Christian Hospital
Enrollment
100
Status
Active, Not Recruiting
Last Updated
7 years ago

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
7 years ago
Study Type
Interventional Study
Sex
All

Investigators

Sponsor
Yonsei University, Wonju Severance Christian Hospital

Eligibility Criteria

Inclusion Criteria

  • The patients (age \= 45 year\-old (yr), smoking history of \= 10 pack\-year (py)) who hospitalized with severe
  • acute exacerbation of chronic obstructive pulmonary disease
  • (All of the patients were diagnosed with COPD, according to the criteria established by the GOLD, and fulfilled the requirements of FEV1 \< 80% and FEV1/forced vital capacity (FVC) \< 70% following inhalation of a bronchodilator. The enrolled patients were also underwent AECOPD with moderate hypercapnic acute respiratory failure (ARF) requiring NIV. Moderate hypercapnic ARF was defined by a partial arterial oxygen tension (PaO2\) of less than 60 mmHg (\<8\.0 kpa) and PaCO2 greater than 45 mmHg (\>6\.0 kpa) characterized by pH levels between 7\.25 and 7\.35\.)

Exclusion Criteria

  • bronchial asthma, malignancy including lung cancer, severe cardiovascular disorder including valvular heart disease, recent myocardial infarction (within 3 months), and pacemaker insertion, severe renal insufficiency requiring hemodialysis and neurological diseases including cerebral infarction or hemorrhage

Outcomes

Primary Outcomes

Not specified

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