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Clinical Trials/NCT02146092
NCT02146092
Completed
Phase 2

Incentive Spirometry Added to Physiotherapy to Reduce Postoperative Pulmonary Complications After Lung Surgery: A Prospective Blinded Randomized Trial

McMaster University1 site in 1 country389 target enrollmentAugust 1, 2014

Overview

Phase
Phase 2
Intervention
Not specified
Conditions
Lung Neoplasms
Sponsor
McMaster University
Enrollment
389
Locations
1
Primary Endpoint
Rate of post operative pulmonary complications within 30 days of surgery
Status
Completed
Last Updated
8 years ago

Overview

Brief Summary

After any surgery, there is a chance of complications. After lung surgery to remove tumours, there is a particularly high chance of a person developing an infection or needing help breathing, called post operative pulmonary complications. Currently, the risk of these complications is reduced through the completion of light physical and deep breathing exercises and walking around as soon as possible after surgery. Another possible way of helping these patients is to use a small device called an Incentive Spirometer to encourage and measure deep breathing. This study wants to compare how often postoperative pulmonary complications happen after major lung surgery between a group completing the exercises alone and a group using the Incentive spirometer in addition to the exercises. It is hoped that the combined therapy will reduce the amount of time patient must stay in hospital, have fewer complication events and have fewer patients re-admitted back into the hospital after they go home, so that patients overall have better outcomes.

Detailed Description

This study is a prospective blinded randomized control trial (RCT) where two arms will be assembled. Consenting eligible patients will be randomized to either the physiotherapy + incentive spirometry (PT+IS-intervention) arm or physiotherapy only (PT-control arm). Patients will be randomized with an equal (1:1) chance of being allocated to either the PT (control) arm or PT+IS (intervention) arm. Both the treating surgeon and data interpreter will be blinded to the intervention.

Registry
clinicaltrials.gov
Start Date
August 1, 2014
End Date
June 2017
Last Updated
8 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Patients must be at minimum age 18
  • Patient must be undergoing pulmonary resection surgery for malignant or benign disease
  • Patients must be able to understand English
  • Patients must be able to demonstrate aptitude and willingness to comply with describes study procedures

Exclusion Criteria

  • Patients who are unable to read and communicate in English
  • Home oxygen usage prior to operation
  • Previous pulmonary resection or any thoracic surgery
  • Radiological evidence of atelectasis or pneumonitis on preoperative imaging
  • Radiological evidence of pleural effusion prior on preoperative imaging
  • Prior exposure to pulmonotoxic drugs such as amiodarone or belomycin
  • Current drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements.
  • Inability or unwillingness of individual or legal guardian/representative to give written informed consent

Outcomes

Primary Outcomes

Rate of post operative pulmonary complications within 30 days of surgery

Time Frame: 30 days after surgery

Postoperative pulmonary complications (PPCs) are defined as: * Pneumonia requiring treatment with antibiotics * Atelectasis requiring pulmonary toilet by bronchoscopy * Respiratory failure requiring treatment via mechanical ventilation (invasive or non-invasive) * Requirement for home oxygen after surgery, when this was not the case prior to surgery

Secondary Outcomes

  • Duration of oxygen treatment in hospital(30 days post-surgery)
  • Length of hospital stay(30 days after surgery)
  • Re-admission to hospital(30 days)
  • Cost effectiveness of spirometry utilization(30 days after surgery)

Study Sites (1)

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