Investigation of the effect of N-acetylcysteine in rheumatoid arthritis

Phase 3

• Conditions: Rheumatoid arthritis.; Rheumatoid arthritis with rheumatoid factor

• Registration Number: IRCT20101014004934N2
• Lead Sponsor: Kashan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 30 November 2020

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 74

Inclusion Criteria

Patient with rheumatoid arthritis
20 to 70 Years old

Exclusion Criteria

Unwillingness to cooperate
Hypo or hyperthyroidism
Use of any supplements (vitamins, minerals and etc) within 3 months prior to enrollment in the study
Incidence of intolerable complications
Current smokers

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Disease activity. Timepoint: At the beginning of the study (before the intervention) and 12 weeks after the intervention. Method of measurement: DAS28-ESR (using a questionnaire for VAS and a checklist to note physical examination results).;Hs-CRP. Timepoint: At the beginning of the study (before the intervention) and 12 weeks after the intervention. Method of measurement: Elisa kit.;ESR. Timepoint: At the beginning of the study (before the intervention) and 12 weeks after the intervention. Method of measurement: mm/h.

Secondary Outcome Measures

Name	Time	Method
Malondialdehyde. Timepoint: At the beginning of the study (before the intervention) and 12 weeks after the intervention. Method of measurement: Spectrophotometry.;Glutathione. Timepoint: At the beginning of the study (before the intervention) and 12 weeks after the intervention. Method of measurement: Spectrophotometry.;Total antioxidant capacity. Timepoint: At the beginning of the study (before the intervention) and 12 weeks after the intervention. Method of measurement: Spectrophotometry.;Morning stiffness duration. Timepoint: At the beginning of the study (before the intervention) and 12 weeks after the intervention. Method of measurement: Minutes.