Testing YAG Laser Iridotomy for Primary Angle-Closure Glaucoma

Not Applicable

Active, not recruiting

• Conditions: Glaucoma Eye; Angle Closure Glaucoma

• Registration Number: NCT07195370
• Lead Sponsor: Isfahan University of Medical Sciences

Brief Summary

This study evaluates the effectiveness and safety of YAG laser peripheral iridotomy performed at two different locations (temporal and inferior) in patients with primary angle-closure glaucoma, a leading cause of blindness worldwide. Patients visiting the glaucoma clinic at Feiz Hospital who are candidates for peripheral iridotomy will participate. In each patient, one eye will receive a temporal iridotomy, and the other eye will receive an inferior iridotomy, with patients unaware of the location used in each eye. The study will measure outcomes such as laser power, intraocular pressure, visual symptoms, and complications over six months to determine which approach is more effective and safer.

Detailed Description

Not available

Study Timeline

• Study Start: 2025-05-01
• Study First Submitted: 2025-08-26
• Status Verified: 2025-09
• Study First Submitted QC: 2025-09-19
• Last Update Submitted: 2025-09-19
• Study First Posted: 2025-09-26
• Last Update Posted: 2025-09-26
• Primary Completion: 2025-10-01
• Study Completion: 2026-01-01

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

Diagnosis of Primary Angle-Closure Glaucoma.

Adults (typically over 40 years old).

Ability to provide informed consent.

Narrow or closed anterior chamber angle (based on gonioscopy).

Intraocular pressure (IOP) controlled with medication but requiring surgery.

No previous iridotomy.

Exclusion Criteria

econdary glaucoma.

Active eye diseases (e.g., infection or inflammation).

Advanced cataracts or lens-related issues.

Severe visual impairment (e.g., less than 20/200 vision).

Uncontrolled systemic diseases (e.g., diabetes or cardiovascular disease).

Pregnancy or breastfeeding.

Previous eye surgery (except for minor procedures).

Inability to follow-up with scheduled visits.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
adverse events	1 day, 1 week, 1month	Surgical and postoperative complications (e.g., bleeding, infection, or changes in intraocular pressure).

Trial Locations

Locations (1)

Isfahan University of Medical Sciences; 🇮🇷 Isfahan, Isfahan, Iran