Intravenous NTG to Preserve Gastric Microcirculation During Gastric Tube Reconstruction
- Conditions
- Esophageal NeoplasmsMicrocirculation
- Registration Number
- NCT00335010
- Lead Sponsor
- Erasmus Medical Center
- Brief Summary
The aim of the present study was to investigate if NTG, administered intravenously during gastric tube reconstruction, could preserve gastric fundus tissue blood flow and oxygenation and reduce the incidence of postoperative leakage.
- Detailed Description
Complications of oesophagectomy and gastric tube reconstruction are leakage and stenosis, which may be due to compromised microvascular blood flow (MBF) in the gastric tissue. We recently demonstrated that peri-operatively decreased MBF could be improved by topical administration of nitro-glycerine NTG). In this present study we investigate the effect of intravenous NTG on gastric microcirculation.
This single centre, prospective, double blinded study randomized thirty-two patients scheduled for esophagectomy into two groups. The intervention group received intravenous NTG during gastric tube reconstruction, as the control group received normal saline.
Baseline values of MBF, microvascular haemoglobin O2 saturation (μHbSO2), and microvascular haemoglobin concentration (μHbcon) were determined at the gastric fundus before and after gastric tube construction and after pulling up the gastric tube to the neck.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 32
- Planned esophagectomy with gastric tube reconstruction
- written informed consent
- ASA I and II
- younger than 18
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method differences in Microvascular bloodflow differences in microvascular hemoglobinsaturation
- Secondary Outcome Measures
Name Time Method differences in anastomotic leakage differences in anastomotic stenosis
Trial Locations
- Locations (1)
Erasmus MC
🇳🇱Rotterdam, Netherlands