Clinical outcomes and cost-effectiveness of a diagnostic and treatment strategy of upfront CTCA plus selective non-invasive functional imaging compared with standard care in patients with chest pain and suspected coronary artery disease

Recruiting

• Conditions: chest pain; coronary artery disease; 10011082

• Registration Number: NL-OMON56132
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 6444

Inclusion Criteria

Outpatient presentation to the cardiologist with chest pain with suspected CAD
- >18 years old

Exclusion Criteria

Patients who meet any of the following criteria will be excluded from
participation:
- Presentation with acute coronary syndrome (NSTEMI/STEMI/unstable angina)
- Acute coronary syndrome (including unstable angina) within past 3 months
- History of obstructive coronary artery disease on imaging (>50% DS)
- History of PCI and / or CABG
- Severe renal failure (eGFR <30 ml/min)
- Severe allergy to iodinated contrast medium
- Known pregnancy
- Patients with an estimated life expectancy of less than 1 year

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. Occurrence of MACE defined as mortality or non-fatal myocardial infarction<br /><br>2. Costs per quality adjusted life year (QALY)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Please see page 10 of the research protocol (Chapter 2.2: Secondary objectives) </p><br>