Prospective Investigation of Multiple Sclerosis in the Three Rivers Region
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 7,500
- 试验地点
- 1
- 主要终点
- Investigate the predictors of the variations in disease trajectory and treatment response
研究概览
简要总结
In this longitudinal prospective natural history study of multiple sclerosis (MS), the overarching goal is to understand the factors that influence individual variation in disease trajectory and treatment response and pave the way for realizing precision medicine in MS. Because MS is a chronic neurological disorder, this observational cohort study will span a 30-year time frame.
详细描述
Research Activities: Initial Questionnaire, Questionnaire for Self-Reported Outcomes, Biological Sample Collection (Blood, Stool, Urine, Cerebrospinal fluid), Genetic Analysis, Standard Quantitative Assessment of Function, Cognitive Assessment, Neuroimaging, Biometric Sensors, Social Network Questionnaire, Connor-Davidson Resilience Scale, NEO Five-Factor Inventory, and the COVID19 Response Surveys.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 7 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Inclusion criteria for MS patients include:
- •Age 7 years or older
- •Willing and able to provide consent (for >=18 years) or assent with permission from at least one of the child's parents (for <18 years)
- •Diagnosis of multiple sclerosis or related disorders, including a first central nervous system demyelinating episode with a positive MRI scan or abnormal MRI scans characteristic of MS but no clinical symptoms of the disease
- •For healthy controls:
- •Age 7 years or older
- •Willing and able to provide consent (for >=18 years) or assent with permission from at least one of the child's parents (for <18 years)
- •No known personal history of multiple sclerosis or related disorders
- •No other chronic diseases
- •Family members, unrelated household controls, or controls from the general population could be eligible
- •There is no exclusion criteria.
排除标准
- 未提供
结局指标
主要结局
Investigate the predictors of the variations in disease trajectory and treatment response
时间窗: within 30 years
Understanding the factors that influence disease trajectory and treatment response will pave the way to realize precision medicine in delivering individualized MS care.
Establish a prospective cohort of well-characterized MS patients and controls
时间窗: within 30 years
For this longitudinal prospective observational study, we will establish a prospective cohort of well-characterized MS patients and controls (2:1).
次要结局
未报告次要终点
研究者
Zongqi Xia
MD, PhD
University of Pittsburgh