Prospective Investigation of Multiple Sclerosis in the Three Rivers Region
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis
- Sponsor
- University of Pittsburgh
- Enrollment
- 7500
- Locations
- 1
- Primary Endpoint
- Investigate the predictors of the variations in disease trajectory and treatment response
- Status
- Recruiting
- Last Updated
- 4 months ago
Overview
Brief Summary
In this longitudinal prospective natural history study of multiple sclerosis (MS), the overarching goal is to understand the factors that influence individual variation in disease trajectory and treatment response and pave the way for realizing precision medicine in MS. Because MS is a chronic neurological disorder, this observational cohort study will span a 30-year time frame.
Detailed Description
Research Activities: Initial Questionnaire, Questionnaire for Self-Reported Outcomes, Biological Sample Collection (Blood, Stool, Urine, Cerebrospinal fluid), Genetic Analysis, Standard Quantitative Assessment of Function, Cognitive Assessment, Neuroimaging, Biometric Sensors, Social Network Questionnaire, Connor-Davidson Resilience Scale, NEO Five-Factor Inventory, and the COVID19 Response Surveys.
Investigators
Zongqi Xia
MD, PhD
University of Pittsburgh
Eligibility Criteria
Inclusion Criteria
- •Inclusion criteria for MS patients include:
- •Age 7 years or older
- •Willing and able to provide consent (for \>=18 years) or assent with permission from at least one of the child's parents (for \<18 years)
- •Diagnosis of multiple sclerosis or related disorders, including a first central nervous system demyelinating episode with a positive MRI scan or abnormal MRI scans characteristic of MS but no clinical symptoms of the disease
- •For healthy controls:
- •Age 7 years or older
- •Willing and able to provide consent (for \>=18 years) or assent with permission from at least one of the child's parents (for \<18 years)
- •No known personal history of multiple sclerosis or related disorders
- •No other chronic diseases
- •Family members, unrelated household controls, or controls from the general population could be eligible
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Investigate the predictors of the variations in disease trajectory and treatment response
Time Frame: within 30 years
Understanding the factors that influence disease trajectory and treatment response will pave the way to realize precision medicine in delivering individualized MS care.
Establish a prospective cohort of well-characterized MS patients and controls
Time Frame: within 30 years
For this longitudinal prospective observational study, we will establish a prospective cohort of well-characterized MS patients and controls (2:1).