Retrospective Study on Registry Data to Evaluate the Impact of Ocrelizumab Used in Routine Care in Patients With RRMS
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis
- Sponsor
- University Hospital, Strasbourg, France
- Enrollment
- 250
- Locations
- 1
- Primary Endpoint
- Retrospective study of the impact of ocrelizumab used in patients with multiple sclerosis
- Last Updated
- 5 years ago
Overview
Brief Summary
Multiple Sclerosis (MS) is a chronic, autoimmune, neurodegenerative disease; clinical events are mainly attributed to myelin destruction and inflammatory of the central nervous system.
The diagnosis resides in clinical and radiological criteria according to 2017 McDonald criteria.
Once the diagnosis of MS has been made, treatment should be initiated promptly, in order to delay the onset of severe disability in the long-term, even more ocrelizumab are a treatment of high efficacy.
Ocrelizumab is used as a first-line or second-line treatment in Relapsing Remitting MS (RRMS) It is an anti-CD20 monoclonal antibody that provides rapid depletion of circulating CD20+ B lymphocytes by complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity.
The main objective is the retrospective evaluation of the impact of ocrelizumab on the outcome of MS.
The secondary objective is the search of predictive factors of response to treatment.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Retrospective study of the impact of ocrelizumab used in patients with multiple sclerosis
Time Frame: Files analysed retrospectively from October 01, 2018 to November 31, 2020 will be examined]