ongterm Intervention Study Allulose

Not Applicable

Conditions: satiety, glucose metabolism, effects on microbiome

Registration Number: DRKS00028521

Lead Sponsor: Max Rubner-Institut

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 12

Inclusion Criteria

• BMI 18,5 – 30 kg/m²
• No intended weight change
• Good general Health
• Written informed consent to participate in the study
• No diseases that affect nutrient absorption, digestion, metabolism or excretion, especially malabsorption or indigestion of fructose
• Clinical parameters for liver and kidney function, carbohydrate and fat metabolism and inflammation markers indicating absence of disease
• No indication of restrictive eating behavior (Dutch Eating Behavior Questionnaire (DEBQ))
• Non- Smokers
• No acute/regular intake of medication that affects fat or carbohydrate metabolism, or gastrointestinal tract
• No intake of antibiotics in the prior 6 months
• No pregnancy or lactation peroid
• Absence of allergy / intolerance against any foods used in the study.

Exclusion Criteria

• Necessity to take certain medications during the study participation
• Appearance of undesirable events
• Appearance of acute diseases during the study participation
• Revocation of consent to participate in the study
• Non-compliance with the study protocol (including hygiene procedures)

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in postprandial concentrations of active GLP-1 in the plasma

Secondary Outcome Measures

Name	Time	Method
• Postprandial plasma concentrations of gut hormones (GIP, PYY, CKK)<br>• Postprandial changes in respiratory quotient<br>• Blood glucose outcomes (Blood glucose, Insulin, c-Peptide, HbA1c, Matsuda Insulin sensitivity index, miRNA)<br>• Metabolite profiles (including sugar profile) in stool, urine, saliva and serum<br>• microbiome composition in stool, urine and saliva<br>• Assessment of the capability of fecal bacteria to degrade Allulose, if applicable isolation, identification and characterization of these gut bacteria<br>• Quantification of bacteria in feces that have the ability to degrade allulose. <br>• Glut5 transporter expression <br>• Excretion rate of allulose<br>