Does ethnicity affect blood pressure regulation?
Recruiting
- Conditions
- Blood pressure regulationCirculatory System
- Registration Number
- ISRCTN38424862
- Lead Sponsor
- niversity of Fribourg - Faculty of Science and Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Male
- Target Recruitment
- 24
Inclusion Criteria
1. Healthy
2. Non-smoking
3. EITHER of South Asian ancestry (India, Pakistan, Bangladesh, Sri Lanka or Nepal) OR Caucasian
4. BMI between 18.5 and 24.9 kg/m²
5. Aged 20-30 years
6. Male
Exclusion Criteria
1. Diagnosed as diabetics based on the following criteria:
1.1. Fasting glucose levels equal to or exceeds 126 mg/dL (7.0 mmol/L)
1.2. 2 HOUR glucose equal to or exceeds 200 mg/dL (11.1 mmol/L)
2. Any medical condition which could interfere with the measured variables, including cardiovascular, gastrointestinal, neurological or overt metabolic disorders
3. Currently using medication for acute or chronic illness
4. Competition athletes
5. Overtly sedentary
6. Eating disorders
7. Fear or have adverse reactions to cannulation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> 1. The following haemodynamic parameters will be assessed continuously, starting with a 30 minute baseline and continued after the oral glucose tolerance test (OGTT) for another 120 minutes using a Task Force Monitor:<br> 1.1. Blood pressure (systolic and diastolic)<br> 1.2. Heart rate<br> 1.3. Stroke volume<br> 1.4. Heather index (marker for myocardial contractility)<br> 2. The following blood parameters will be assessed at the end of the 30 minute baseline and after the OGTT every 30 minutes until the end of the OGTT (120 minutes post-drink):<br> 2.1. Plasma glucose, assessed using hexokinase Glucose HK Gen 3<br> 2.2. Plasma insulin, assessed using ELISA<br>
- Secondary Outcome Measures
Name Time Method