The effect and mechanism of Si-Jun-Zi decoction on the function of intestinal mucosal barrier during chemotherapy for colorectal cancer

Not Applicable

• Conditions: Colorectal cancer

• Registration Number: ITMCTR1900002838
• Lead Sponsor: Putuo Hospital, Shanghai University of Traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. have no chemotherapy, containing 5-Fu adjuvant chemotherapy, can complete the above plan course of high-risk stage II, III postoperative patients with colorectal cancer;
2. syndrome characteristics in line with the above TCM diagnostic criteria;
3. Aged 18-80 years;
4. Pg-sga <=8 points;
5. WHO PS score 0 to 1;
6. with normal liver and kidney function.

Exclusion Criteria

(1) mental patients and delirium, unable to communicate with the language of patients;
(2) there are serious liver, kidney, heart and brain organs organic or functional lesions;
(3) pregnant and nursing women;
(4) Patients with definite other intestinal diseases in the recent 3 months;
(5) In recent 3 months, patients who took drugs related to intestinal barrier function protection.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Intestinal barrier function;

Secondary Outcome Measures

Name	Time	Method
TCM syndrome information;Nutritional status;intestinal flora;immune state;