Effects of Dietary Folate and Phytate Zinc Absorption: Zinc Amino Acid Complexes vs. Zinc-chloride

Not Applicable

Completed

• Conditions: Dietary Zinc Absorption
• Interventions: Other: Regular toast and juice; Other: High phytate toast and juice; Other: Regular toast and juice, with folic acid

• Registration Number: NCT05273710
• Lead Sponsor: University of California, Berkeley

Brief Summary

The purpose of this study is to determine the effects of consuming a small breakfast of juice and toast with added phytate or with taking a folic acid supplement on the absorption of a small amount of zinc that is either bound to amino acids or to chloride or picolinate. The results of this study will provide new information on how components of diet (e.g., phytate, and folic acid) affect the absorption of different forms of dietary zinc (e.g., zinc bound to amino acids, zinc chloride, and zinc picolinate).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-03-01
• Study First Submitted QC: 2022-03-01
• Study First Posted: 2022-03-10
• Study Start: 2022-03-28
• Primary Completion: 2022-11-16
• Study Completion: 2022-11-16
• Status Verified: 2022-12
• Last Update Submitted: 2022-12-19
• Last Update Posted: 2022-12-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 10

Inclusion Criteria

• Apparently healthy men (i.e., have no current health issues requiring medications or a specific diet), 19 to 50 years of age, with a body mass index between 18 and 30 kg/m2, and willing to eat only the foods provided by the study for 17 days

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Exclusion Criteria

• Those reporting current chronic or acute diseases or HIV diagnosis, food allergies, smoking tobacco or marijuana, alcohol abuse, any contraindication to venipuncture such as bleeding disorders or use of blood thinners; use of illicit drugs; regular consumption of medications, micronutrient supplements, or both. Vegetarians, or those unable to eat meat, are also excluded since the foods for the study contain meat.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Zinc absorption study	Regular toast and juice	Zinc absorption is determined from each of 3 test meals in all subjects.
Zinc absorption study	High phytate toast and juice	Zinc absorption is determined from each of 3 test meals in all subjects.
Zinc absorption study	Regular toast and juice, with folic acid	Zinc absorption is determined from each of 3 test meals in all subjects.

Primary Outcome Measures

Name	Time	Method
Fractional zinc absorption	48 hours	Oral zinc tracer to tracee ratio in plasma, as a fraction of intravenous zinc tracer to tracee ratio

Trial Locations

Locations (1)

University of California; 🇺🇸 Berkeley, California, United States