Analgesic efficacy of nefopam for acute postoperative pain after ankle fracture surgery: triple-blind randomized controlled trial
- Conditions
- To reduce morphine use and morphine related side effect for postoperative pain control after ankle fracture fixationAnkle fracture, nefopam, morphine, postoperative pain, ankle fracture fixation
- Registration Number
- TCTR20240618002
- Lead Sponsor
- Research Facilitation Division, Faculty of Medicine Vajira Hospital, Navamindradhiraj University
- Brief Summary
The two groups were comparable regarding their characteristics. From 12 hours post-operatively onwards, the nefopam group reported lower VAS pain scores, with significant differences at both 12 hours postoperatively and 16 hours postoperatively. There is a statistically significant overall VAS pain score between groups. Total morphine consumption was significantly lower in the nefopam group during 48 hours postoperatively.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 46
1. Age 15-70 years old
2. American Society of Anesthesiologists (ASA) physical status) class I, II and III
3. Undergo ankle fracture fixation
1. Contraindication for nefopam
2. History of allergic to any drugs in study protocol
3. History of opioids use within 3 months
4. Contraindication for spinal anesthesia
5. Peripheral neuropathies
6. Multi-organ injuries
7. Cognitive impairment
8. Pregnancy
9. Refuse to join study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method pain by visual analog scale 48 hours postoperative visual analog scale
- Secondary Outcome Measures
Name Time Method morphine consumption 48 hours Total dose of morphine ,Time to first dose of morhpine 0-48 hours Time to first dose of morhpine,side effects of morphine 48 hours side effects of morphine,side effects of nefopam 48 hours side effects of nefopam