Exploring the Cortical Hemodynamic Response of Excitatory Brain Stimulation: a Pilot Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy
- Sponsor
- The Hong Kong Polytechnic University
- Enrollment
- 24
- Locations
- 1
- Primary Endpoint
- Oxygenated hemoglobin (HbO) change compared to baseline
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Intermittent theta-burst stimulation (iTBS) is a promising treatment for major depressive disorder. However, fewer than 50% of patients show sufficient response. Therefore, the optimal treatment protocol is worth investigating. Recent studies show that the relationship between stimulation intensity and prefrontal hemodynamic response is not linear but in an inverse U-shape by exploring the hemodynamic changes before and after iTBS. Concurrent transcranial magnetic stimulation (TMS)/functional near-infrared spectroscopy (fNIRS) setup allows the investigators to observe the prefrontal hemodynamic response during stimulation.
The aim of this study is to investigate the effects of different intensities on brain activity during and after the stimulation using fNIRS.
Detailed Description
Please refer to the full proposal
Investigators
Dr Georg Kranz
Principal Investigator
The Hong Kong Polytechnic University
Eligibility Criteria
Inclusion Criteria
- •Right-handed
Exclusion Criteria
- •history of epilepsy, seizures, or convulsions
- •current or past diagnosis of neurological disorders, such as head injuries, strokes, encephalitis, epilepsy, Parkinson's, or Alzheimer's
- •current or past diagnosis of psychiatric disorders, such as depression, anxiety, schizophrenia, or autism
- •with metal implants, such as a cochlear implant, neurostimulator, or cardiac pacemaker
Outcomes
Primary Outcomes
Oxygenated hemoglobin (HbO) change compared to baseline
Time Frame: During and post TBS-fNIRS measurement, up to 3 months
iTBS-induced HbO change in the DLPFC before, during and after stimulation
Secondary Outcomes
- Oxygen saturation change compared to baseline(During and post TBS-fNIRS measurement, up to 3 months)
- Deoxygenated hemoglobin (HbR) Change compared to baseline(During and post TBS-fNIRS measurement, up to 3 months)