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Clinical Trials/NCT00806715
NCT00806715CompletedNot Applicable

Impact of Iron Overload in Pediatric Patients Undergoing Stem Cell Transplantation

Boston Children's Hospital1 site in 1 country38 target enrollmentStarted: February 2007Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
38
Locations
1
Primary Endpoint
Hepatic iron content as measured by R2 MRI.
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

The goal of this study is to examine the impact of iron overload in patients undergoing a bone marrow transplant. We believe that the iron status in these patients is associated with complications for transplant survivors. We will examine the iron status in these patients by MRI and by screening for mutations in genes known to cause iron overload. We will also determine the levels of hepcidin (a hormone produced in the liver that appears to regulate iron homeostasis) from blood and urine.

Study Design

Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Eligibility Criteria

Ages
5 Years to — (Child, Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Not provided

Exclusion Criteria

  • Not provided

Outcomes

Primary Outcomes

Hepatic iron content as measured by R2 MRI.

Time Frame: Pre-HSCT and Day 100

Secondary Outcomes

  • Genetic determinants of iron overload- HFE status.(Pre-HSCT)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Deborah Chirnomas

Instructor

Boston Children's Hospital

Study Sites (1)

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