Effect of L-PRF and A-PRF in Ridge Preservation

Not Applicable

Completed

• Conditions: Ridge Preservation; Atrophic Maxilla
• Interventions: Other: A-PRF; Other: L-PRF

• Registration Number: NCT03268512
• Lead Sponsor: Universitaire Ziekenhuizen KU Leuven

Brief Summary

A split-mouth design study will be performed regarding the use of platelet concentrates on ridge preservation: L-PRF vs A-PRF vs control. Patient needing multiple teeth extractions in the upper jaw (single-rooted teeth) will be recruited. The use of each platelet concentrate or control will be randomized by means of a computer program. The results will be analysed clinical and radiographically (CBCT). When the subject will choose for implant rehabilitation, a biopsy will be taken in the site of the preserved sockets. The region will be localized with a customized stent, fabricated with the position of the extracted teeth. VAS scales will be provided to evaluate the post-operative discomfort.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-08-22
• Study First Submitted: 2017-08-28
• Study First Submitted QC: 2017-08-30
• Study First Posted: 2017-08-31
• Status Verified: 2018-10
• Primary Completion: 2018-10-10
• Study Completion: 2018-10-10
• Last Update Submitted: 2018-10-10
• Last Update Posted: 2018-10-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• 3 single-rooted teeth needed to be extracted in the upper jaw
• patient in good general health as documented by self-assessment
• patients must be committed to the study and must be willing to sing the informed consent.

Exclusion Criteria

• any systemic medical condition that could interfere with the surgical procedure or planned treatment.
• current pregnancy or breast feeding
• radiotherapy or chemotherapy in head and neck area
• intravenous and oral bisphosphonate
• patients smoking >20 cig/day
• unwillingness to return for the follow-up examination

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
A-PRF	A-PRF	One socket will be filled with A-PRF membranes and covered with at least 2 A-PRF membranes. A modified horizontal mattress will be place as suture to keep the A-PRF in place.
L-PRF	L-PRF	One socket will be filled with L-PRF membranes and covered with at least 2 L-PRF membranes. A modified horizontal mattress will be place as suture to keep the L-PRF in place.

Primary Outcome Measures

Name	Time	Method
Changes horizontal width at crest -1mm	3 months	Primary outcome variables were defined as the changes in horizontal width at crest-1 mm levels.

Secondary Outcome Measures

Name	Time	Method
Changes horizontal width at crest -3 mm and 5 mm; vertical resorption; socket fill	3 months	Changes in horizontal width at crest -3 mm and 5 mm; vertical resorption at the lingual and buccal side; socket fill.

Trial Locations

Locations (1)

UZ Leuven; 🇧🇪 Leuven, Vlaams-Brabant, Belgium