Alveolar Ridge Preservation Following Tooth Extraction Using Advanced Platelet Rich Fibrin (A-PRF) Versus Platelet Rich Fibrin (PRF) A Randomized Clinical Trail :Comparative Study
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Change in bucco-lingual dimensions
研究概览
简要总结
the aim of this study is clinically and radiographically evaluate the use of advance platelet rich fibrin (A-PRF) versus platelet rich fibrin (PRF) in preservation of alveolar ridge following tooth extraction
详细描述
systemically healthy patients who have at least one non-restorable tooth in the upper inter-bicuspid region and are not seeking immediate or early implant treatment will be allocated in this study after performing nonsurgical periodontal therapy and preoperative periapical therapy to evaluate and improve the condition of the periodontal tissues.
Anesthesia will be given then flapless atraumatic extraction using periotomes followed by forceps after luxation. For all groups, the socket will be debrided using curette then
- group A, the socket will be filled with A.PRF
- group B the socket will be filled with PRF.
- group C no bio-additive will be added.
- Criss cross horizontal mattress suture will be applied to close the extraction wound.
PRF and A-PRF preparation :
10 ml of blood will be drawn from each patient by vein puncture of the antecubital vein.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with at least one non restorable tooth in upper inter-bicuspid region.
- •Stable periodontal condition with no acute periapical infection.
- •Systematically healthy conditions.
- •Cooperative patients.
- •Intact buccal plate of bone.
排除标准
- •Patients seeking immediate or early implants.
- •Pregnant females.
- •Bone diseases.
- •Drugs and diseases that may affect platelet count or function.
结局指标
主要结局
Change in bucco-lingual dimensions
时间窗: 6 months
clinical measurement using bone caliper in mm numerical
次要结局
- bone dentistry(6 months)
- postoperative pain scores(2 weeks)
- change in alveolar bone height(6 months)
- soft tissue healing(6 months)
研究者
Reem Mahmoud AbdAlhameed AbuBasha
principal investigator
Cairo University