Evaluation of Biomarkers Involved In Bone Metabolism (Remodeling) In Periimplanter Crevicular Fluid of Implants With Early Marginal Bone Loss: A Retrospective Clinical Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 59
- 试验地点
- 1
研究概览
简要总结
This study aimed to compare biological mediators known to be important in peri-implant diseases in implants with and without early stage marginal bone loss. A total of 118 implants in 59 patients were designated as test and control groups. The radiographic and periodontal data of the included implants, along with peri-implant sulcus fluid samples, were evaluated.
详细描述
This study included clinical and radiographic records of patients who received implant treatment in the maxilla and/or mandible between 11/2021 and 9/2024. Patients were divided into test and control groups based on the presence/absence of EMBL after prosthetic loading. Periodontal clinical measurements were recorded and peri-implant sulcus fluid (PISF) samples were collected. Sclerostin, calprotectin, type I collagen cross-linked N-telopeptide (NTx), matrix metalloproteinase (MMP)-8, and MMP-9 levels were analyzed using ELISA. Group comparisons were performed with the statistical analyses.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Presence of 1 mm or more of radiographic marginal bone loss within the first 3 months after implant placement
- •Availability of radiographic documentation
- •Availability of demographic data, surgical records, and data related to the implant used
- •Physical condition classified as Class I and II according to the American Society of Anesthesiologists (ASA) classification
- •Patients with no smoking history in the last 10 years
- •Fixed implant-supported restorations
- •Screw-retained implants
排除标准
- •Patients receiving and/or maintaining implant treatment at centers other than the Department of Periodontology, Pamukkale University Faculty of Dentistry
- •Patients with incomplete or unreachable files or radiographic documentation
- •Patients with a known systemic disease/condition that alters their physical condition or bone metabolism
- •Severe bruxism cases
- •Pregnant and breastfeeding patients
- •Patients with incomplete implant-supported prosthesis
- •Areas grafted during or before implant surgery
- •Removable implant-supported restorations
- •Cement-retained implants
- •Patients undergoing peri-implantitis treatment
研究者
Raziye Tugce Can Keles
Research Assistant
Pamukkale University