NCT00491140已完成不适用
Retrospective Study Assessing Molecular Features Predicting Response or Resistance to Cetuximab Therapy in Metastatic Colorectal Cancer Patients
Istituto Clinico Humanitas1 个研究点 分布在 1 个国家目标入组 85 人开始时间: 2006年12月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 85
- 试验地点
- 1
- 主要终点
- Association of different biomarkers with Cetuximab sensitivity
研究概览
简要总结
The primary objective is to identify molecular features predicting response or resistance to cetuximab
详细描述
Secondary objective is to investigate association of genomic status of EGFR and HER-2 genes with clinical outcome, including objective response, time to progression and survival
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histologically confirmed diagnosis of colorectal cancer with available tumor tissue and clinical data; presence of at least one measurable lesion.
排除标准
- •Less than 3 weeks after completion of previous radiotherapy
结局指标
主要结局
Association of different biomarkers with Cetuximab sensitivity
时间窗: Assessment every two months
次要结局
- Association of different biomarkers with time to progression and survival(At the end of the study)
研究者
研究点 (1)
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