NCT00864266已完成不适用
Biological Factors Predicting Response to Chemotherapy in Advanced Non Small Cell Lung Cancer : a Prospective Study
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 试验地点
- 6
- 主要终点
- Response rate
研究概览
简要总结
The primary aim of the study is to identify a predictive molecular signature for response to chemotherapy, according to WHO criteria, in patients with non-small cell lung cancer by studying the transcriptome (miRNAs and mRNAs) and the single nucleotide polymorphism (SNPs) by using high throughput techniques.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histological diagnosis of non-small-cell lung cancer (NSCLC)
- •Obtention of a biopsy of the tumour according to the procedure defined in the protocol
- •NSCLC of any stage to be treated by standard conventional first-line chemotherapy, as defined in the ELCWP guidelines (www.elcwp.org)
- •Presence of at least one assessable lesion
- •Availability for participating in the detailed follow-up of the protocol
- •Signed informed consent.
- •Age above 18 years
排除标准
- •Patient who was previously treated with chemotherapy for NSCLC or who has any contra-indication precluding the administration of conventional chemotherapy for NSCLC
- •NSCLC treated by exclusive surgery or radiotherapy
- •A history of prior malignant tumour, except non-melanoma skin cancer or in situ carcinoma of the cervix or of the bladder or cured malignant tumour (more than 5-year disease free interval)
研究组 & 干预措施
1
Experimental
After obtaining the biopsy, patients will be treated by standard chemotherapy (the regimen has to be in agreement with the ELCWP guidelines, available on the website www.elcwp.org)
干预措施: Chemotherapy (Drug)
结局指标
主要结局
Response rate
时间窗: response will be assessed every 3 cycles of chemotherapy according to WHO criteria
次要结局
- Progression-free survival(Period between the date of treatment and the date of first progression or death)
- Duration of response(period between the day of treatment and the date of first progression in patients with an objective response)
- Survival(Survival will be dated from the date of treatment)
研究者
研究点 (6)
Loading locations...
相似试验
Unknown
不适用
Molecular Markers of Chemosensitivity for Bladder CancerEffects of ChemotherapyBladder CancerNCT02074241Southwest Hospital, China200
招募中
不适用
Prediction of the effect of chemotherapy and prognosis based on gene and metabolome analysis by specimen collected by EUSFNA on pancreatic cancerpancreatic cancerJPRN-UMIN000026261Division of Gastroenterology, Department of Internal medicine, Kobe University Graduate School of Medicine250
已完成
不适用
Identification of Biomarkers for Prediction of Response or Resistance Against Target Therapy in Gastric CancerEsophageal NeoplasmsStomach NeoplasmsNCT02305043University of Leipzig549
Unknown
不适用
Molecular Determinants for Therapy Response on Renal Cell CarcinomaRenal Cell CarcinomaNCT02208128Heidelberg University4
终止
不适用
Biomarker Development for Response Prediction by DNA Mutational AnalysisNeoplasm MetastasisNCT01855061P.O. Witteveen79