Dabigatran for Peri Procedural Anticoagulation During Radiofrequency Ablation of Atrial Fibrillation
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- The incidence of peri-procedural major bleeding complications
研究概览
简要总结
It is hypothesized that peri-ablation Dabigatran will be a safe and effective method of peri-procedural anticoagulation for Atrial Fibrillation (AF) ablation, resulting in a low rate of peri-procedural bleeding and thromboembolic complications.
详细描述
All patients will be initiated on fixed dose Dabigatran 150 mg BID at least one month prior to the ablation procedure. If patients were already on warfarin therapy, then warfarin should be stopped for a minimum of 2 days prior to Dabigatran initiation, when the INR is less than 2. Patients will remain on the same dose of Dabigatran until the day before ablation. On the day prior to ablation, patients will not take any Dabigatran, nor will any be taken on the day of ablation, until after sheath removal.
For patients in high-risk groups for bleeding, the lower dose of Dabigatran may be used, or the drug may be stopped further in advance of the procedure. For patients with age greater than 80 years old, the lower dose of Dabigatran (110 mg BID) may be used as an alternative. For patients with impaired renal function, the lower dose may be used, but the drug may be stopped earlier in advance of the procedure as per the suggestions in Appendix A.
Post-ablation, Dabigatran will be started at the same dose - either 150 mg or 110 mg - as before the ablation procedure. Dabigatran will be initiated 8 hours post sheath removal and continue twice daily until the three month follow-up.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients age 18 or greater.
- •Patients undergoing first-time catheter ablation for AF.
- •Patients with paroxysmal or persistent AF. Paroxysmal AF will be defined as self-terminating episodes less than 7 days duration. Persistent AF will be defined as episodes that last longer than 7 days duration or episodes requiring termination by electrical or chemical cardioversion.
- •Patients with symptomatic AF that is refractory to at least one antiarrhythmic medication. "Symptomatic" patients are those who have been aware of their AF anytime within the last 5 years prior to enrollment. Symptoms may include, but are not restricted to, palpitations, shortness of breath, chest pain, fatigue, left ventricular dysfunction, or other symptoms, or any combination of the above.
- •At least one episode of AF must have been documented by ECG, Holter, loop recorder, telemetry, or transtelephonic monitoring within 24 months of entry in the trial.
- •Patients must be able and willing to provide written informed consent to participate in the clinical trial.
排除标准
- •Patients with AF felt to be secondary to an obvious reversible cause (e.g. thyroid disease, post-surgical).
- •Patients with contraindications to systemic anticoagulation with heparin or a direct thrombin inhibitor.
- •Patients with severe renal impairment (creatinine clearance of <30 ml/min)
- •Patients with left atrial size >/= 60 mm (2D echocardiography, parasternal long axis view).
- •Patients who are or may potentially be pregnant or who are not on an effective method of birth control or who are planning to get pregnant during the study.
- •Patients with mechanical heart valves.
- •Patients who are undergoing repeat catheter ablation of AF.
- •Patients with hemorrhagic manifestations, bleeding diathesis, or patients with impairment of hemostasis.
- •Lesions at risk of clinically significant bleeding - such as extensive cerebral infarction within the last 6 months, active peptic ulcer disease with recent bleeding.
- •Concomitant treatment with strong P-glycoprotein inhibitors, i.e. ketoconazole.
- •Known hypersensitivity to Dabigatran or Dabigatran etexilate.
研究组 & 干预措施
Dabigatran
Dabigatran will be compared to historical data using other OAC methods for Pulmonary Vein Ablation
干预措施: dabigatran (Drug)
结局指标
主要结局
The incidence of peri-procedural major bleeding complications
时间窗: 1 month prior to Pulmonary Vein Ablation and three months post ablation.
次要结局
未报告次要终点