Improving Patient Outcome Following Autologous Chondrocyte Implantation: Accelerated versus Conservative Rehabilitatio

Not Applicable

Completed

• Conditions: Physical Medicine / Rehabilitation - Other physical medicine / rehabilitation; Articular Cartilage Defects in the Knee; Musculoskeletal - Other muscular and skeletal disorders

• Registration Number: ACTRN12609000756224
• Lead Sponsor: niversity of Western Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2009-09-01
• Study Completion: 2013-01-20
• Last Update Posted: 12 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

Male or female subjects; Aged between 16-65 years; Localised, full thickness medial or lateral femoral condylar defects (<10cm2 upon MRI evaluation); Trochlear or patella defects, provided they are in conjunction with a primary condylar defect; Chondral or osteochondral lesions; Ligamentous deficiencies, provided they are addressed prior to or at the time of surgery; Acceptance of rehabilitation procedure by subject; Having provided written informed consent.

Exclusion Criteria

Multiple defects; Isolated trochlear or patella defects; Presence of ongoing, progressive inflammatory arthritis; Unstable knee joint; Obesity exceeding >35 using the body mass index (BMI); Varus or valgus abnormalities (>+2°; <-5° (tibiofemoral anatomical angle)); Known allergy towards gentamycin or hypersensitivity; Known allergy towards products of bovine or porcine origin; Osteonecrosis; Chondrocalcinosis; Osteoarthritis; Rheumatoid arthritis; Infectious diseases; and Pregnancy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified