Remifentanil Requirement for Acceptable Intubating Condition With Two Dose Ketamine Without Neuromuscular Blocking Agent in Children
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 51
- 试验地点
- 1
- 主要终点
- acceptability of intubation condition
研究概览
简要总结
Ketamine and opioid are known to improve the intubating condition, respectively. Combination of ketamine and opioid potentiate analgesic effect and give hemodynamic stability in complementary manner. Therefore, the combination use of ketamine and remifentanil could be useful for acceptable intubating condition in the general anesthesia without the use of neuromuscular blocking agent. Generally, induction dose of ketamine ranges between 1 and 2 mg. There was no report about the optimal dose of remifentanil with 1 or 2 mg ketamine induction dose for intubation without neuromuscular blocking agent. The investigators focus on remifentanil dose using Dixon's up and down method.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 3 Years 至 12 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Undergoing general anesthesia with endotracheal tube
排除标准
- •Anticipated difficult airway
- •Patient with upper respiratory infection within 14 days
研究组 & 干预措施
ketamine 1
Anesthesia induction with ketamine 1 mg followed by remifentanil.
干预措施: Ketamine 1 (Drug)
ketamine 1
Anesthesia induction with ketamine 1 mg followed by remifentanil.
干预措施: Remifentanil (Drug)
ketamine 2
Anesthesia induction with ketamine 2 mg followed by remifentanil.
干预措施: Ketamine 2 (Drug)
ketamine 2
Anesthesia induction with ketamine 2 mg followed by remifentanil.
干预措施: Remifentanil (Drug)
结局指标
主要结局
acceptability of intubation condition
时间窗: during and after intubation, about 2 minute
For assessment of intubation condition, 5 variables will be individually evaluated though 3 point scale (excellent, good, poor). If all variables are graded as excellent, intubation condition will be excellent. If at least 1 variable is poor, it will be reported as poor. Otherwise, it will be reported as good. Good and excellent will be considered to be acceptable intubating condition. Poor will be reported as unacceptable intubating condition. 1. Laryngoscope easiness 2. Vocal cord position 3. Vocal cord movement 4. Movement of limb 5. Coughing
次要结局
未报告次要终点
研究者
yun jeong chae
Associate Professor
Ajou University School of Medicine