Turgut Ozal Medical Center Department of Anesthesiology and Reanimation

Inonu University1 site in 1 country60 target enrollmentJuly 2014

Overview

Brief Summary

The investigators evaluate the effects of a subanesthetic dose of ketamine, administered as an adjunct to sevoflurane, on duration of seizure activity, hemodynamic profile and recovery times during electroconvulsive therapy (ECT) in patients with major depression.

Detailed Description

Patients will randomly allocate, to either a sevoflurane-ketamine (Group SK), sevoflurane-saline (Group SS) receiving group. Mean arterial pressure (MAP) and heart rate (HR) will record prior to anesthetic induction (T1); following anesthetic induction (T2); and 0, 1, 3, and 10 min after the seizure has ended (T3, T4, T5, and T6, respectively). Motor and EEG seizure durations will be recorded.

Registry

clinicaltrials.gov

Start Date

July 2014

End Date

October 2014

Last Updated

11 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Inonu University

Responsible Party

Principal Investigator

Feray Erdil

Associated Professor

Inonu University

Eligibility Criteria

Inclusion Criteria

•Major depressive patients

Exclusion Criteria

•Pregnancy
•Have a history of myocardial infarction in the previous six months
•Atrial fibrillation or flutter
•Heart block
•Unregulated hypertension
•Cerebrovascular diseases
•A known drug allergy

Arms & Interventions

Group SK

Sevoflurane was initiated, in both groups, at 8% for anesthesia induction until loss of consciousness was achieved, at which point it was discontinued. Following loss of consciousness ketamine was administered to Group SK (n=29) in the form of a 0.5mg/kg iv bolus. Patients in Group SS (n=30) received saline in the same manner.

Intervention: Sevoflurane

Group SK

Sevoflurane was initiated, in both groups, at 8% for anesthesia induction until loss of consciousness was achieved, at which point it was discontinued. Following loss of consciousness ketamine was administered to Group SK (n=29) in the form of a 0.5mg/kg iv bolus. Patients in Group SS (n=30) received saline in the same manner.

Intervention: Ketamine

Group SS

Sevoflurane was initiated, in both groups, at 8% for anesthesia induction until loss of consciousness was achieved, at which point it was discontinued. Patients in Group SS (n=30) received saline in the same manner.

Intervention: Sevoflurane

Group SS

Sevoflurane was initiated, in both groups, at 8% for anesthesia induction until loss of consciousness was achieved, at which point it was discontinued. Patients in Group SS (n=30) received saline in the same manner.

Intervention: Saline