Remifentanil Requirement for Acceptable Intubating Condition

Phase 4

Completed

• Conditions: Intubating Condition
• Interventions: Drug: Ketamine 2; Drug: Ketamine 1; Drug: Remifentanil

• Registration Number: NCT02655380
• Lead Sponsor: Ajou University School of Medicine

Brief Summary

Ketamine and opioid are known to improve the intubating condition, respectively. Combination of ketamine and opioid potentiate analgesic effect and give hemodynamic stability in complementary manner. Therefore, the combination use of ketamine and remifentanil could be useful for acceptable intubating condition in the general anesthesia without the use of neuromuscular blocking agent. Generally, induction dose of ketamine ranges between 1 and 2 mg. There was no report about the optimal dose of remifentanil with 1 or 2 mg ketamine induction dose for intubation without neuromuscular blocking agent. The investigators focus on remifentanil dose using Dixon's up and down method.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-01-08
• Study First Submitted QC: 2016-01-12
• Study First Posted: 2016-01-14
• Study Start: 2017-06-19
• Primary Completion: 2018-04-16
• Study Completion: 2018-04-16
• Status Verified: 2019-01
• Last Update Submitted: 2019-01-08
• Last Update Posted: 2019-01-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 51

Inclusion Criteria

• ASA I-II
• Undergoing general anesthesia with endotracheal tube

Exclusion Criteria

• Anticipated difficult airway
• Patient with upper respiratory infection within 14 days
• Asthma

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
ketamine 2	Ketamine 2	Anesthesia induction with ketamine 2 mg followed by remifentanil.
ketamine 1	Ketamine 1	Anesthesia induction with ketamine 1 mg followed by remifentanil.
ketamine 1	Remifentanil	Anesthesia induction with ketamine 1 mg followed by remifentanil.
ketamine 2	Remifentanil	Anesthesia induction with ketamine 2 mg followed by remifentanil.

Primary Outcome Measures

Name	Time	Method
acceptability of intubation condition	during and after intubation, about 2 minute	For assessment of intubation condition, 5 variables will be individually evaluated though 3 point scale (excellent, good, poor). If all variables are graded as excellent, intubation condition will be excellent. If at least 1 variable is poor, it will be reported as poor. Otherwise, it will be reported as good. Good and excellent will be considered to be acceptable intubating condition. Poor will be reported as unacceptable intubating condition.; 1. Laryngoscope easiness; 2. Vocal cord position; 3. Vocal cord movement; 4. Movement of limb; 5. Coughing

Trial Locations

Locations (1)

Ajou universitiy school of medicine; 🇰🇷 Suwon-si, Gyeong-gi Do, Korea, Republic of