Renal Functional Magnetic Resonance Imaging in Healthy Persons - Reproducibility and Impact of Stress
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Reproducibility
研究概览
简要总结
The main purpose of the study is to describe the applicability and reproducibility of functional MRI scans of the kidneys in healthy participants. Furthermore, the study examines to what extent physiological stress caused by lying in a scanner affects the renal perfusion and thus the reproducibility
详细描述
2 groups of 10 healthy participants each are included. 1 group aged 18 to 40 and a group of participants above 60 years of age.
The functional MRI sequences are performed consecutively in a protocol set up on a 1,5 T MRI scanner.
In totl, 3 identical scans are being performed. 2 scans on day 1 followed by another scan 1-2 weeks later. Before and after each scan, cortisol and copeptin is controlled in a blood sample to quantify the level of physiological stress.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age between 18 and 40
- •Age of 60 or above
排除标准
- •Known kidney or cardiovascular disease
- •Medicine of any kind, that must be taken on days of scanning
- •MRi incompatible implants or other contraindications to MRi
- •Claustrophobia
- •Not being able to lie still in an hour
- •Body weight above 110 kg or waist circumference above 95 cm
- •Pregnancy
结局指标
主要结局
Reproducibility
时间窗: Results from scans performed with an interval of 1 to 2 weeks are compared
Reproducibility as a coefficient of variation
Physiological stress
时间窗: Results from scans performed with an interval of 1 to 2 weeks are compared
Quantified by level of cortisol and copeptin in blood samples.
次要结局
未报告次要终点