Renal Functional Magnetic Resonance Imaging in Healthy Persons - Reproducibility and Impact of Stress
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy
- Sponsor
- University of Aarhus
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Reproducibility
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The main purpose of the study is to describe the applicability and reproducibility of functional MRI scans of the kidneys in healthy participants. Furthermore, the study examines to what extent physiological stress caused by lying in a scanner affects the renal perfusion and thus the reproducibility
Detailed Description
2 groups of 10 healthy participants each are included. 1 group aged 18 to 40 and a group of participants above 60 years of age. The functional MRI sequences are performed consecutively in a protocol set up on a 1,5 T MRI scanner. In totl, 3 identical scans are being performed. 2 scans on day 1 followed by another scan 1-2 weeks later. Before and after each scan, cortisol and copeptin is controlled in a blood sample to quantify the level of physiological stress.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age between 18 and 40
- •Age of 60 or above
Exclusion Criteria
- •Known kidney or cardiovascular disease
- •Medicine of any kind, that must be taken on days of scanning
- •MRi incompatible implants or other contraindications to MRi
- •Claustrophobia
- •Not being able to lie still in an hour
- •Body weight above 110 kg or waist circumference above 95 cm
- •Pregnancy
Outcomes
Primary Outcomes
Reproducibility
Time Frame: Results from scans performed with an interval of 1 to 2 weeks are compared
Reproducibility as a coefficient of variation
Physiological stress
Time Frame: Results from scans performed with an interval of 1 to 2 weeks are compared
Quantified by level of cortisol and copeptin in blood samples.