The Effects of Sufentanil vs. Remifentanil in Total Intravenous Anesthesia With Remimazolam on Postoperative Pain

Not Applicable

Recruiting

• Conditions: Stomach Neoplasms
• Interventions: Drug: sufentanil-remimazolam group; Drug: remifentanil-remimazolam group

• Registration Number: NCT05785234
• Lead Sponsor: Yonsei University

Brief Summary

In this study, the investigators evaluate the effect of total intravenous anesthesia using sufentanil-remimazolam and remifentanil-remimazolam on postoperative pain in patients undergoing laparoscopic gastrectomy.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-02-28
• Status Verified: 2023-03
• Study First Submitted QC: 2023-03-21
• Last Update Submitted: 2023-03-21
• Study First Posted: 2023-03-27
• Last Update Posted: 2023-03-27
• Study Start: 2023-04
• Primary Completion: 2025-03
• Study Completion: 2025-06

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 66

Inclusion Criteria

1. 20years or older
2. Scheduled for laparoscopic-assisted gastrectomy
3. American Society of Anesthesiologists(ASA) physical status I and III

Exclusion Criteria

1. Emergency operation
2. Patients with a history of severe hypersensitivity reaction to dextran 40
3. Patients who cannot use patient controlled analgesia(PCA)
4. Patients with morbid obesity [body mass index (BMI) >35 kg/m2]
5. Patients with history of uncontrolled hypertension (diastolic BP >110mmHg) or DM
6. Patients with history of heart failure (unstable angina, congestive heart failure)
7. Patients with history of liver failure, renal failure, allergic to medicine
8. Patients with history of cerebrovascular disease (cerebral hemorrhage, cerebral ischemia)
9. Patients with history of uncontrolled psychiatric disease (PTSD, anxiety, depression)
10. Patients with obstructive sleep apnea
11. Patients who cannot read the consent form (examples: Illiterate, foreigner)
12. Patients who withdraw the consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sufentanil-remimazolam group	sufentanil-remimazolam group	The sufentanil-remimazolam group receives total intravenous anesthesia with sufentanil-remimazolam.
Remifentanil-remimazolam group	remifentanil-remimazolam group	The remifentanil-remimazolam group receives total intravenous anesthesia with remifentanil-remimazolam.

Primary Outcome Measures

Name	Time	Method
Total consumption of fentanyl in 24 hours after surgery	after 24 hours postoperative period	To investigate the effect of total intravenous anesthesia with intraoperative sufentanil-remimazolam and remifentanil-remimazolam on postoperative pain, total cumulative dose of fentanyl was measured for the first postoperative 24 hour.

Trial Locations

Locations (1)

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine; 🇰🇷 Seoul, Korea, Republic of