The Effects of Sufentanil-remimazolam vs. Remifentanil-remimazolam Total Intravenous Anesthesia on Postoperative Pain in Laparoscopic-assisted Gastrectomy - A Randomized, Controlled Study-
Overview
- Phase
- Not Applicable
- Intervention
- sufentanil-remimazolam group
- Conditions
- Stomach Neoplasms
- Sponsor
- Yonsei University
- Enrollment
- 66
- Locations
- 1
- Primary Endpoint
- Total consumption of fentanyl in 24 hours after surgery
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
In this study, the investigators evaluate the effect of total intravenous anesthesia using sufentanil-remimazolam and remifentanil-remimazolam on postoperative pain in patients undergoing laparoscopic gastrectomy.
Investigators
Eligibility Criteria
Inclusion Criteria
- •20years or older
- •Scheduled for laparoscopic-assisted gastrectomy
- •American Society of Anesthesiologists(ASA) physical status I and III
Exclusion Criteria
- •Emergency operation
- •Patients with a history of severe hypersensitivity reaction to dextran 40
- •Patients who cannot use patient controlled analgesia(PCA)
- •Patients with morbid obesity \[body mass index (BMI) \>35 kg/m2\]
- •Patients with history of uncontrolled hypertension (diastolic BP \>110mmHg) or DM
- •Patients with history of heart failure (unstable angina, congestive heart failure)
- •Patients with history of liver failure, renal failure, allergic to medicine
- •Patients with history of cerebrovascular disease (cerebral hemorrhage, cerebral ischemia)
- •Patients with history of uncontrolled psychiatric disease (PTSD, anxiety, depression)
- •Patients with obstructive sleep apnea
Arms & Interventions
Sufentanil-remimazolam group
The sufentanil-remimazolam group receives total intravenous anesthesia with sufentanil-remimazolam.
Intervention: sufentanil-remimazolam group
Remifentanil-remimazolam group
The remifentanil-remimazolam group receives total intravenous anesthesia with remifentanil-remimazolam.
Intervention: remifentanil-remimazolam group
Outcomes
Primary Outcomes
Total consumption of fentanyl in 24 hours after surgery
Time Frame: after 24 hours postoperative period
To investigate the effect of total intravenous anesthesia with intraoperative sufentanil-remimazolam and remifentanil-remimazolam on postoperative pain, total cumulative dose of fentanyl was measured for the first postoperative 24 hour.