Effect of Three Doses of Sufentanil on Anesthesia Introduction and Recovery Quality in Pediatric Adenotonsillectomy
Overview
- Phase
- Not Applicable
- Intervention
- Sufentanil Injection
- Conditions
- Sufentanil
- Sponsor
- Tongji Hospital
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- adequate sufentanil dose
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
To study the effect of different doses of sufentanil on anesthesia induction and analgesia after tonsillectomy in children. According to the different doses of sufentanil used in anesthesia induction, the children were divided into 3groups. The vital signs during anesthesia, the recovery period of anesthesia and the complications after anesthesia were compared among the groups. The anesthetic effects and safety of sufentanil at different doses were discussed, which provided theoretical basis for clinical selection of the best drug dosage.
Detailed Description
Fifteen minutes before operation, midazolam 0.1 mg/kg was slowly intravenously injected. Five minutes later, the child entered the operating room. Pi, Narcotrend, blood pressure, ECG, SpO2 and body temperature were monitored. Penehyclidine hydrochloride 0.01 mg/kg, dexamethasone 0.1 mg/kg, propofol 3 mg/kg, sufentanil (0.3μg/kg, 0.4 μg/kg, 0.5 μg/kg) were given during anesthesia induction. cis-atracurium 0.15 mg/kg, using the required type of tube for tracheal intubation. Sevoflurane 1.0 MAC + remifentanil 0.15 ug/kg/min 50% oxygen was given during anesthesia maintenance. Effective analgesia was achieved by adjusting the dosage of remifentanil during operation. The changes of vital signs including perfusion index, Narcotrend, Bp, HR, oxygen saturation were observed before anesthesia induction, immediately after tracheal intubation, during tonsillectomy and adenoidectomy during operation, after extubation and in the recovery room. Then record the recovery time, restlessness and pain score during recovery period, postoperative pain, nausea and vomiting and other complications.
Investigators
aijun xu
associate professor
Tongji Hospital
Eligibility Criteria
Inclusion Criteria
- •Age 1-12 years,
- •ASA I-II grade;
- •selective adenotonsillectomy
- •BMI 18.5～23.9,
- •Sign informed consent
Exclusion Criteria
- •Emergency surgery;
- •Abnormal liver and kidney function
- •severe dehydration and malnutrition or Hb \< 10g/dl;
- •BMI \<18.5 or \<23.9;
- •Children with neurological disorders
Arms & Interventions
S1 group
Sufentanil 0.3 μg/kg was intravenously given during anesthesia induction
Intervention: Sufentanil Injection
S2 group
Sufentanil 0.4 μg/kg was intravenously given during anesthesia induction
Intervention: Sufentanil Injection
S3 group
Sufentanil 0.5 μg/kg was intravenously given during anesthesia induction
Intervention: Sufentanil Injection
Outcomes
Primary Outcomes
adequate sufentanil dose
Time Frame: 24 hours
Adequate sufentanil dose is determined by Optimal intubation conditions and No hypotension or other severe side effects
Secondary Outcomes
- cut off value of Pi for valid stress assessment(24 hours)
- Narcotrend index(24 hours)
- postoperative complications with different doses of sufentanil(7days)