Comparison of Several Oxygenation Targets With Different Oxygen Interfaces - Impact on Oxygen Flow Rates

Not Applicable

Not yet recruiting

• Conditions: Oxygen Toxicity; COPD Bronchitis; Respiratory Failure

• Registration Number: NCT06646991
• Lead Sponsor: Laval University

Brief Summary

Oxygen therapy is at the heart of the healthcare system. Oxygen flow rates depend on a number of confounding factors confounding factors (target used, skin pigmentation, pulse oximeter used, etc.) The investigators have recently have recently demonstrated that the combination of these factors (different peripheral oxygen saturation (SpO2) targets and different oximeters) can have a significant impact on oxygen flows rates. The effect on oxygen flow was not simply additive .

The aim of this study is to evaluate the impact of the interface used on oxygen flow rates in different patient populations (main objective). The investigatoers also evaluate the impact of the interface on carbon dioxide (PaCO2), in particular with closed oxygen masks, with which rebreathing is theoretically possible (secondary objective).

secondary objective).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-06-17
• Study First Submitted QC: 2024-10-16
• Study First Posted: 2024-10-17
• Status Verified: 2024-11
• Last Update Submitted: 2024-11-20
• Last Update Posted: 2024-11-22
• Study Start: 2024-12
• Primary Completion: 2025-06
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Adult (> or = 18 years old)
• Ongoing on conventional oxygen therapy with peripheral oxygen saturation (SpO2) between 88 and 100% with the usual oximeter
• SpO2 < 92% ambient air with the usual oximeter

Exclusion Criteria

• No SpO2 signal with with the usual oximeter
• False nails or nail polish
• Severe anemia documented on last blood count during current hospitalization (haemoglobin (Hb) < 80g/L)
• Oxygen flow > 6 L/min

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Oxygen flow	Mean Oxygen flow in the five last minute of each study period (between minute 10 and 15)	Oxygen flows (or fraction of inspired oxygen (FiO2)) at the end of each study period (last minute average) to reach peripheral oxygen saturation (SpO2) target to reach SpO2 target with specific oxygen administration interfaces

Secondary Outcome Measures

Name	Time	Method
Partial oxygen weaning	Mean oxygen flow in the five last minute of each study period (between minute 10 and 15)	Rate of partial oxygen weaning (Oxygen flow \<=0.5 L/min)
Complete oxygen weaning	Mean oxygen flow in the five last minute of each study period (between minute 10 and 15)	Rate of complete oxygen weaning (Oxygen flow =0 L/min or FiO2 0.21)

Trial Locations

Locations (1)

Institut Universitaire de Cardiologie et de Pneumologie de Québec; 🇨🇦 Quebec, Canada